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- W71439645 abstract "Abstract Long-lived plasma cells (PCs) are terminally differentiated B cells that reside in the spleen and bone marrow where they secrete antibody for a life-time. Although PCs are the cellular arbiters of humoral immunity, the signals required for formation of long-lived antibody secreting PCs remain poorly defined. In addition, how long-lived PCs resist apoptosis in response to ionizing radiation (IR) is also not understood. We find that resistance to IR-induced apoptosis occurs exceptionally early, within three days, during PC differentiation. IR-resistance is even established in PCs following immunization with NP-LPS, a type 1 thymus-independent (TI-1) antigen thought to generate only short-lived PCs. We have exploited this finding by administering IR in vivo to investigate the lifespan of antigen-specific NP-LPS induced PCs months after immunization. Contrary to current models, we find immunization with NP-LPS, a response which neither requires T-cell help nor elicits germinal center formation, is sufficient to drive the formation of long-lived IR-resistant PCs. Further, we find that resistance to IR-induced apoptosis is a cell intrinsic property unique to PCs and is not shared by other activated B cells. These findings establish radioresistance as a novel property of very early PCs and challenge the popular view that TI-1 antigens are unable to elicit the formation of long-lived PCs." @default.
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- W71439645 date "2010-04-01" @default.
- W71439645 modified "2023-09-23" @default.
- W71439645 title "T-independent antigens induce the formation of long-lived plasma cells (132.18)" @default.
- W71439645 doi "https://doi.org/10.4049/jimmunol.184.supp.132.18" @default.
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