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- W71470894 abstract "Obesity is an increasing health problem for many western countries, manifested in a heterogeneous group of associated disorders. Obesity itself is defined as a disorder of energy balance, where energy intake exceeds energy expenditure. Understanding the molecular mechanisms and environmental cues which drive a somatic stem cell to a preadipocyte and further to a mature adipocyte may enable us to fight obesity on a molecular level by designing effective drug treatments to reduce adipose tissue mass with small or no side effects for the patients. The microarray technology is a powerful means to generate a gene expression profile, which allows to simultaneously observe the activity of thousands of genes in one experiment. The objective was to establish a cell culture model system to study the transcriptional mechanisms which are involved in adipogenesis in vitro. A cell line of murine bone marrow stromal (BMS) cells has been proven to be capable of undergoing adipogenesis upon proper induction. A supplementation of growth medium with dexamethasone and indomethacin massively induced adipogenesis. This was evidenced by oil red O staining. BMS cells are known to have somatic stem cell character, being able to differentiate into osteocytes, chondrocytes, adipocytes, haematopoiesis-supporting cells and even non-mesodermal cells. The established cell line was investigated for its in vivo properties via an in vivo transplantation assay. The results show that these cells are able to form bone, adipocytes and a complete haematopoietic microenvironment. Further, the reciprocity of the cells was tested, by means of re-differentiating a mature adipocytic culture into a culture showing an osteogenic phenotype. Finally, microarray assays were performed in order to delineate transcriptional regulatory networks." @default.
- W71470894 created "2016-06-24" @default.
- W71470894 creator A5088623617 @default.
- W71470894 date "2002-01-01" @default.
- W71470894 modified "2023-09-23" @default.
- W71470894 title "Large Scale Gene Expression Profiling during Adipogenesis of Murine Bone Marrow Stromal Cells" @default.
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