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• W71541410 abstract "Omans WB, Leuterer W, Gyorgy P. J Pediatr 1963;62:98-106 In an effort to test the acceptability and toxicity of protein-rich foods mandated by the World Health Organization and the United Nations Children's Fund, formulas prepared from soy protein were studied in rats and in premature infants. Premature infants were selected because of their rapid growth and prolonged hospitalization. Formulas (4 soy-based and 1 cow milk–based formulas) were evaluated in rats on the basis of the protein efficiency ratio (gram of weight gain per gram of test protein). Despite similar total protein contents, all soy formulas had lower protein efficiency ratio values than the cow milk–based formula. Clinical studies in premature infants were conducted over a 24-week period, encompassing both hospital and home monitoring. Significantly lower rates of growth (measured as the food efficiency ratio [weight gain per 100 mL formula]) and serum protein levels were observed in the infants fed soy-based formulas compared with those fed the cow milk–based formula. Infants fed soy-based formulas also manifest lower serum phosphorus and cholesterol values than those fed cow milk–based formula. There were more adverse effects in the soy-based group, such as diarrhea and perianal dermatitis. The study did note that differences among the soy-based formulas suggested that processing of the soy milk may be a factor. Nevertheless, the conclusion of the studies was that soy-based formula had an inferior biologic value to cow milk–based formula and that such soy-based formulas should not be used as a primary food source for infants. In the 50 years since this report, neonatal nutritionists continue to remind us of the facts identified in this study but soy-based formulas remain available, accounting for nearly 25% of the formulas marketed in the US.1Bhatia J. Greer F. Committee on NutritionUse of soy protein-based formulas in infant feeding.Pediatrics. 2008; 121: 1062-1068Crossref PubMed Scopus (264) Google Scholar These studies indirectly identified the presence of phosphate binders and the hypocholesterolemic effects of soy milk. It is now routine manufacturing practice to add additional minerals (calcium, phosphorus, iron, zinc) to account for this intrinsic binding. Thus, we do not recommend the use of soy milks for infants, and we especially never recommend these milks to premature infants. In contrast, adults may favor the hypocholesterolemic effects of a soy diet!" @default.
• W71541410 created "2016-06-24" @default.
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• W71541410 date "2013-01-01" @default.
• W71541410 modified "2023-09-27" @default.
• W71541410 title "50 Years Ago in The Journal of Pediatrics" @default.
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• W71541410 doi "https://doi.org/10.1016/j.jpeds.2012.07.038" @default.
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