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- W71596970 abstract "Epithelial cells line the gastrointestinal (GI) mucosa and form an important barrier to a wide array of noxious substances in the lumen. Disruption of this barrier function occurs commonly in various critical illnesses, such as trauma, burns, hemorrhage, sepsis, and massive surgical operations, leading to the translocation of luminal toxic substances and bacteria to the blood stream. Maintenance of the GI epithelial integrity is a complex process that is critically controlled by numerous factors at different levels, but the exact mechanisms involved in this process are far from clear. Over the past decade, it has been shown that polyamines are necessary for normal integrity of the GI epithelium under physiological and various pathological conditions. Polyamines are required for GI epithelial restitution after injury and also implicated in expression of intercellular junction proteins. Increasing evidence indicates that polyamines regulate rapid epithelial restitution and intercellular junction expression in association with their ability to modulate activity of voltage-gated K+ channels (Kv) and cytosolic free Ca2+ concentration ([Ca2+]cyt). In this chapter, we will provide an overview of regulatory effects of cellular polyamines on Kv channels and intercellular junctions in intestinal epithelial cells." @default.
- W71596970 created "2016-06-24" @default.
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- W71596970 date "2006-01-01" @default.
- W71596970 modified "2023-10-16" @default.
- W71596970 title "Regulation of Kv Channel Activity and Intercellular Junctions by Polyamines in Intestinal Epithelial Cells" @default.
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- W71596970 doi "https://doi.org/10.1007/978-1-59745-145-1_21" @default.
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