FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W71609746> ?p ?o ?g. }

• W71609746 endingPage "3862" @default.
• W71609746 startingPage "3856" @default.
• W71609746 abstract "Abstract Thymic negative selection renders the developing T-cell repertoire tolerant to self-major histocompatability complex (MHC)/peptide ligands. The major mechanism of induction of self-tolerance is thought to be thymic clonal deletion, ie, the induction of apoptotic cell death in thymocytes expressing a self-reactive T-cell receptor. Consistent with this hypothesis, in mice deficient in thymic clonal deletion mediated by cells of hematopoietic origin, a twofold to threefold increased generation of mature thymocytes has been observed. Here we describe the analysis of the specificity of T lymphocytes developing in the absence of clonal deletion mediated by hematopoietic cells. In vitro, targets expressing syngeneic MHC were readily lysed by activated CD8+ T cells from deletion-deficient mice. However, proliferative responses of T cells from these mice on activation with syngeneic antigen presenting cells were rather poor. In vivo, deletion-deficient T cells were incapable of induction of lethal graft-versus-host disease in syngeneic hosts. These data indicate that in the absence of thymic deletion mediated by hematopoietic cells functional T-cell tolerance can be induced by nonhematopoietic cells in the thymus. Moreover, our results emphasize the redundancy in thymic negative selection mechanisms." @default.
• W71609746 created "2016-06-24" @default.
• W71609746 creator A5027201117 @default.
• W71609746 creator A5072568067 @default.
• W71609746 date "1999-06-01" @default.
• W71609746 modified "2023-09-28" @default.
• W71609746 title "In Vivo T-Lymphocyte Tolerance in the Absence of Thymic Clonal Deletion Mediated by Hematopoietic Cells" @default.
• W71609746 cites W1525658012 @default.
• W71609746 cites W1528584436 @default.
• W71609746 cites W1531758726 @default.
• W71609746 cites W1561274962 @default.
• W71609746 cites W1576863849 @default.
• W71609746 cites W1580308596 @default.
• W71609746 cites W1584516103 @default.
• W71609746 cites W1588628033 @default.
• W71609746 cites W1590531419 @default.
• W71609746 cites W1592276905 @default.
• W71609746 cites W1600574786 @default.
• W71609746 cites W1923424513 @default.
• W71609746 cites W1965045795 @default.
• W71609746 cites W1966709711 @default.
• W71609746 cites W1969681282 @default.
• W71609746 cites W1971765600 @default.
• W71609746 cites W1972419122 @default.
• W71609746 cites W1981653287 @default.
• W71609746 cites W1987203358 @default.
• W71609746 cites W1988497921 @default.
• W71609746 cites W1996373540 @default.
• W71609746 cites W2003243065 @default.
• W71609746 cites W2004275733 @default.
• W71609746 cites W2008061114 @default.
• W71609746 cites W2009401513 @default.
• W71609746 cites W2010315866 @default.
• W71609746 cites W2014650854 @default.
• W71609746 cites W2016878829 @default.
• W71609746 cites W2023053069 @default.
• W71609746 cites W2023236971 @default.
• W71609746 cites W2025872773 @default.
• W71609746 cites W2029060163 @default.
• W71609746 cites W2029487548 @default.
• W71609746 cites W2035223596 @default.
• W71609746 cites W2035910941 @default.
• W71609746 cites W2036839389 @default.
• W71609746 cites W2043388415 @default.
• W71609746 cites W2044512941 @default.
• W71609746 cites W2046465303 @default.
• W71609746 cites W2049843929 @default.
• W71609746 cites W2053670375 @default.
• W71609746 cites W2056374213 @default.
• W71609746 cites W2060409041 @default.
• W71609746 cites W2060827478 @default.
• W71609746 cites W2066172186 @default.
• W71609746 cites W2070379407 @default.
• W71609746 cites W2073474757 @default.
• W71609746 cites W2073905541 @default.
• W71609746 cites W2079065623 @default.
• W71609746 cites W2079683161 @default.
• W71609746 cites W2081109704 @default.
• W71609746 cites W2093578282 @default.
• W71609746 cites W2094561643 @default.
• W71609746 cites W2096992142 @default.
• W71609746 cites W2099876234 @default.
• W71609746 cites W2106416311 @default.
• W71609746 cites W2109168421 @default.
• W71609746 cites W2111694672 @default.
• W71609746 cites W2113334969 @default.
• W71609746 cites W2132156332 @default.
• W71609746 cites W2135277567 @default.
• W71609746 cites W2148377905 @default.
• W71609746 cites W2149746365 @default.
• W71609746 cites W2157651568 @default.
• W71609746 cites W2158679391 @default.
• W71609746 cites W2162508156 @default.
• W71609746 cites W2174800991 @default.
• W71609746 cites W2615548860 @default.
• W71609746 doi "https://doi.org/10.1182/blood.v93.11.3856" @default.
• W71609746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10339493" @default.
• W71609746 hasPublicationYear "1999" @default.
• W71609746 type Work @default.
• W71609746 sameAs 71609746 @default.
• W71609746 citedByCount "21" @default.
• W71609746 countsByYear W716097462013 @default.
• W71609746 countsByYear W716097462016 @default.
• W71609746 crossrefType "journal-article" @default.
• W71609746 hasAuthorship W71609746A5027201117 @default.
• W71609746 hasAuthorship W71609746A5072568067 @default.
• W71609746 hasConcept C104317684 @default.
• W71609746 hasConcept C109159458 @default.
• W71609746 hasConcept C141231307 @default.
• W71609746 hasConcept C147483822 @default.
• W71609746 hasConcept C153911025 @default.
• W71609746 hasConcept C154317977 @default.
• W71609746 hasConcept C167672396 @default.
• W71609746 hasConcept C19317047 @default.
• W71609746 hasConcept C202751555 @default.
• W71609746 hasConcept C203014093 @default.
• W71609746 hasConcept C207936829 @default.
• W71609746 hasConcept C2776090121 @default.

• next