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- W71670111 abstract "Intracisternal injection of newborn animals with 6-hydroxydopamine (6-OH-DA) results in destruction of a large part of the locus coerul= eus (LC), regeneration of cerebellar noradrenergic fibres, and striking defects in the development of the cerebellum in the rat. Subcutaneous injection of 6-OH-DA leads to overgrowth of noradrenergic fibres and marginal alterations in cerebellar growth. The differences in the sprouting response of the NA fibres after ic. or sc. 6-OH-DA (incomplete regrowth and striking overgrowth, respectively) are reflected in similar changes of brain stem and cerebellar NA content and 3 H-NA uptake. The developmental pattern of A content in both regions is not altered by 6-OH-DA treatment. Following ic. 6-OH-DA injection, brain stem DA levels are reduced by 30% in between day 15 and 60 after birth." @default.
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- W71670111 date "1979-01-01" @default.
- W71670111 modified "2023-10-14" @default.
- W71670111 title "THE LOCUS COERULEUS NEUROBLASTS: PLASTICITY AND FUNCTION IN DEVELOPMENT" @default.
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- W71670111 doi "https://doi.org/10.1016/b978-1-4832-8363-0.50260-3" @default.
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