FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W71690915> ?p ?o ?g. }

• W71690915 abstract "CONTEXT: There are no controlled studies on surgical treatment of diffuse low-grade gliomas (LGGs), and management is controversial.OBJECTIVE: To examine survival in population-based parallel cohorts of LGGs from 2 Norwegian university hospitals with different surgical treatment strategies.DESIGN, SETTING, AND PATIENTS: Both neurosurgical departments are exclusive providers in adjacent geographical regions with regional referral practices. In hospital A diagnostic biopsies followed by a wait and scan approach has been favored (biopsy and watchful waiting), while early resections have been advocated in hospital B (early resection). Thus, the treatment strategy in individual patients has been highly dependent on the patient's residential address. Histopathology specimens from all adult patients diagnosed with LGG from 1998 through 2009 underwent a blinded histopathological review to ensure uniform classification and inclusion. Follow-up ended April 11, 2011. There were 153 patients (66 from the center favoring biopsy and watchful waiting and 87 from the center favoring early resection) with diffuse LGGs included.MAIN OUTCOME MEASURE: The prespecified primary end point was overall survival based on regional comparisons without adjusting for administered treatment. Results Initial biopsy alone was carried out in 47 (71%) patients served by the center favoring biopsy and watchful waiting and in 12 (14%) patients served by the center favoring early resection (P < .001). Median follow-up was 7.0 years (interquartile range, 4.5-10.9) at the center favoring biopsy and watchful waiting and 7.1 years (interquartile range, 4.2-9.9) at the center favoring early resection (P=.95). The 2 groups were comparable with respect to baseline parameters. Overall survival was significantly better with early surgical resection (P=.01). Median survival was 5.9 years (95% CI, 4.5-7.3) with the approach favoring biopsy only while median survival was not reached with the approach favoring early resection. Estimated 5-year survival was 60% (95% CI, 48%-72%) and 74% (95% CI, 64%-84%) for biopsy and watchful waiting and early resection, respectively. In an adjusted multivariable analysis the relative hazard ratio was 1.8 (95% CI, 1.1-2.9, P=.03) when treated at the center favoring biopsy and watchful waiting.CONCLUSIONS: For patients in Norway with LGG, treatment at a center that favored early surgical resection was associated with better overall survival than treatment at a center that favored biopsy and watchful waiting. This survival benefit remained after adjusting for validated prognostic factors." @default.
• W71690915 created "2016-06-24" @default.
• W71690915 creator A5087314005 @default.
• W71690915 date "2013-01-01" @default.
• W71690915 modified "2023-09-28" @default.
• W71690915 title "Risks and benefits of brain tumor surgery : A balancing act" @default.
• W71690915 cites W1488580241 @default.
• W71690915 cites W1504656305 @default.
• W71690915 cites W1539664312 @default.
• W71690915 cites W1624957772 @default.
• W71690915 cites W1887747927 @default.
• W71690915 cites W1964194009 @default.
• W71690915 cites W1994222210 @default.
• W71690915 cites W2001264853 @default.
• W71690915 cites W2002330540 @default.
• W71690915 cites W2028896946 @default.
• W71690915 cites W2038629933 @default.
• W71690915 cites W2040909865 @default.
• W71690915 cites W2048458879 @default.
• W71690915 cites W2052136636 @default.
• W71690915 cites W2064214863 @default.
• W71690915 cites W2074385832 @default.
• W71690915 cites W2075528869 @default.
• W71690915 cites W2083225173 @default.
• W71690915 cites W2093540934 @default.
• W71690915 cites W2096287682 @default.
• W71690915 cites W2096476820 @default.
• W71690915 cites W2110236737 @default.
• W71690915 cites W2118311655 @default.
• W71690915 cites W2125372543 @default.
• W71690915 cites W2133611748 @default.
• W71690915 cites W2141570482 @default.
• W71690915 cites W2141699748 @default.
• W71690915 cites W2153836018 @default.
• W71690915 cites W2156713230 @default.
• W71690915 cites W2161190434 @default.
• W71690915 cites W2161524493 @default.
• W71690915 cites W2162643152 @default.
• W71690915 cites W2473786944 @default.
• W71690915 cites W2043398771 @default.
• W71690915 hasPublicationYear "2013" @default.
• W71690915 type Work @default.
• W71690915 sameAs 71690915 @default.
• W71690915 citedByCount "0" @default.
• W71690915 crossrefType "dissertation" @default.
• W71690915 hasAuthorship W71690915A5087314005 @default.
• W71690915 hasConcept C119060515 @default.
• W71690915 hasConcept C121608353 @default.
• W71690915 hasConcept C126322002 @default.
• W71690915 hasConcept C126838900 @default.
• W71690915 hasConcept C141071460 @default.
• W71690915 hasConcept C151730666 @default.
• W71690915 hasConcept C2775934546 @default.
• W71690915 hasConcept C2776135927 @default.
• W71690915 hasConcept C2776141087 @default.
• W71690915 hasConcept C2779343474 @default.
• W71690915 hasConcept C2780192828 @default.
• W71690915 hasConcept C512399662 @default.
• W71690915 hasConcept C61434518 @default.
• W71690915 hasConcept C71924100 @default.
• W71690915 hasConcept C86803240 @default.
• W71690915 hasConceptScore W71690915C119060515 @default.
• W71690915 hasConceptScore W71690915C121608353 @default.
• W71690915 hasConceptScore W71690915C126322002 @default.
• W71690915 hasConceptScore W71690915C126838900 @default.
• W71690915 hasConceptScore W71690915C141071460 @default.
• W71690915 hasConceptScore W71690915C151730666 @default.
• W71690915 hasConceptScore W71690915C2775934546 @default.
• W71690915 hasConceptScore W71690915C2776135927 @default.
• W71690915 hasConceptScore W71690915C2776141087 @default.
• W71690915 hasConceptScore W71690915C2779343474 @default.
• W71690915 hasConceptScore W71690915C2780192828 @default.
• W71690915 hasConceptScore W71690915C512399662 @default.
• W71690915 hasConceptScore W71690915C61434518 @default.
• W71690915 hasConceptScore W71690915C71924100 @default.
• W71690915 hasConceptScore W71690915C86803240 @default.
• W71690915 hasLocation W716909151 @default.
• W71690915 hasOpenAccess W71690915 @default.
• W71690915 hasPrimaryLocation W716909151 @default.
• W71690915 hasRelatedWork W1482892948 @default.
• W71690915 hasRelatedWork W1512928716 @default.
• W71690915 hasRelatedWork W1724454487 @default.
• W71690915 hasRelatedWork W1985469426 @default.
• W71690915 hasRelatedWork W1997826297 @default.
• W71690915 hasRelatedWork W1998527256 @default.
• W71690915 hasRelatedWork W2003592212 @default.
• W71690915 hasRelatedWork W2003798418 @default.
• W71690915 hasRelatedWork W2009342364 @default.
• W71690915 hasRelatedWork W2039860243 @default.
• W71690915 hasRelatedWork W2076348889 @default.
• W71690915 hasRelatedWork W2085428370 @default.
• W71690915 hasRelatedWork W2091243732 @default.
• W71690915 hasRelatedWork W2093969506 @default.
• W71690915 hasRelatedWork W2095343161 @default.
• W71690915 hasRelatedWork W2110106044 @default.
• W71690915 hasRelatedWork W2207554953 @default.
• W71690915 hasRelatedWork W2529147570 @default.
• W71690915 hasRelatedWork W2753132480 @default.
• W71690915 hasRelatedWork W2903456564 @default.
• W71690915 isParatext "false" @default.

• next