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- W71824488 abstract "We have investigated the quantitative accuracy of fully 3D PET using model-based scatter correction by measuring the half-life of Ga-68 in the presence of scatter from F-18. The inner chamber of a Data Spectrum cardiac phantom was filled with 18.5 MBq of Ga-68. The outer chamber was filled with an equivalent amount of F-18. The cardiac phantom was placed in a 22x30.5 cm elliptical phantom containing anthropomorphic lung inserts filled with a water-Styrofoam mixture. Ten frames of dynamic data were collected over 13.6 hours on Siemens-CTI 953B scanner with the septa retracted. The data were corrected using model-based scatter correction, which uses the emission images, transmission images and an accurate physical model to directly calculate the scatter distribution. Both uncorrected and corrected data were reconstructed using the Promis algorithm. The scatter correction required 4.3% of the total reconstruction time. The scatter fraction in a small volume of interest in the center of the inner chamber of the cardiac insert rose from 4.0% in the first interval to 46.4% in the last interval as the ratio of F-18 activity to Ga-68 activity rose from 1:1 to 33:1. Fitting a single exponential to the last three data points yields estimates of themore » half-life of Ga-68 of 77.01 minutes and 68.79 minutes for uncorrected and corrected data respectively. Thus, scatter correction reduces the error from 13.3% to 1.2%. This suggests that model-based scatter correction is accurate in the heterogeneous attenuating medium found in the chest, making possible quantitative, fully 3D PET in the body.« less" @default.
- W71824488 created "2016-06-24" @default.
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- W71824488 date "1994-05-01" @default.
- W71824488 modified "2023-09-23" @default.
- W71824488 title "Quantitative fully 3D PET via model-based scatter correction" @default.
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