Matches in SemOpenAlex for { <https://semopenalex.org/work/W71873315> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W71873315 abstract "The purpose of this work is to investigate the relation of hydration and the degree of crystallinity for poly (ethylene oxide) (PEO) tablets using Raman spectroscopic methods and complementary thermal analysis for pharmaceutical interests. The influence of the tableting process is also investigated by measuring the degree of crystallinity and the melting point of PEO powder and tablets. The hydration of the PEO tablets is performed in different relative (RH) humidity environments and the water uptake and the degree of crystallinity of the tablets are measured by TGA and DSC. The dry and hydrated tablets are investigated by Raman spectroscopy. The low frequency region in the Raman spectrum reflects the degree of crystallinity of PEO. The DSC results show a decrease in the degree of crystallinity by tableting and the hydration process. However, the slight decrease in the degree of crystallinity of PEO does not show significant difference in the low frequency Raman spectra, only a slight broadening of the LAM band, at 280 cm-1, is observed. By measuring the PEO tablet immersed in water the hydration process can be followed in-situ with Raman spectroscopy. With changes from dry (fully crystalline) to wet state (amorphous), changes in band intensity and shape are found at 230 cm-1, 280 cm-1, 363 cm-1, 535 cm-1 and 580 cm-1. During hydration, the bands at 230 cm-1 and 363 cm-1 decrease in intensity and the sharp LAM band at 280 cm-1 is replaced by the broad D-LAM band. Among the vibrational bands observed, the band at 363 cm-1 is the most suitable to quantitatively follow the ingress of water into the PEO tablet and the continuous decrease of the degree of crystallinity, due to the least interference of the spectral compounds." @default.
- W71873315 created "2016-06-24" @default.
- W71873315 creator A5066770961 @default.
- W71873315 date "2011-01-01" @default.
- W71873315 modified "2023-09-23" @default.
- W71873315 title "Investigating Polymer Conformation in Poly (Ethylene Oxide) (PEO) Based Systems for Pharmaceutical Applications A Raman Spectroscopic Study of the Hydration Process" @default.
- W71873315 hasPublicationYear "2011" @default.
- W71873315 type Work @default.
- W71873315 sameAs 71873315 @default.
- W71873315 citedByCount "0" @default.
- W71873315 crossrefType "dissertation" @default.
- W71873315 hasAuthorship W71873315A5066770961 @default.
- W71873315 hasConcept C113196181 @default.
- W71873315 hasConcept C120665830 @default.
- W71873315 hasConcept C121332964 @default.
- W71873315 hasConcept C127413603 @default.
- W71873315 hasConcept C13530604 @default.
- W71873315 hasConcept C158960510 @default.
- W71873315 hasConcept C15920480 @default.
- W71873315 hasConcept C159985019 @default.
- W71873315 hasConcept C178790620 @default.
- W71873315 hasConcept C185592680 @default.
- W71873315 hasConcept C191897082 @default.
- W71873315 hasConcept C192562407 @default.
- W71873315 hasConcept C2777801237 @default.
- W71873315 hasConcept C2779849058 @default.
- W71873315 hasConcept C2779851234 @default.
- W71873315 hasConcept C40003534 @default.
- W71873315 hasConcept C42360764 @default.
- W71873315 hasConcept C46275449 @default.
- W71873315 hasConcept C521977710 @default.
- W71873315 hasConcept C56052488 @default.
- W71873315 hasConcept C8010536 @default.
- W71873315 hasConcept C97355855 @default.
- W71873315 hasConceptScore W71873315C113196181 @default.
- W71873315 hasConceptScore W71873315C120665830 @default.
- W71873315 hasConceptScore W71873315C121332964 @default.
- W71873315 hasConceptScore W71873315C127413603 @default.
- W71873315 hasConceptScore W71873315C13530604 @default.
- W71873315 hasConceptScore W71873315C158960510 @default.
- W71873315 hasConceptScore W71873315C15920480 @default.
- W71873315 hasConceptScore W71873315C159985019 @default.
- W71873315 hasConceptScore W71873315C178790620 @default.
- W71873315 hasConceptScore W71873315C185592680 @default.
- W71873315 hasConceptScore W71873315C191897082 @default.
- W71873315 hasConceptScore W71873315C192562407 @default.
- W71873315 hasConceptScore W71873315C2777801237 @default.
- W71873315 hasConceptScore W71873315C2779849058 @default.
- W71873315 hasConceptScore W71873315C2779851234 @default.
- W71873315 hasConceptScore W71873315C40003534 @default.
- W71873315 hasConceptScore W71873315C42360764 @default.
- W71873315 hasConceptScore W71873315C46275449 @default.
- W71873315 hasConceptScore W71873315C521977710 @default.
- W71873315 hasConceptScore W71873315C56052488 @default.
- W71873315 hasConceptScore W71873315C8010536 @default.
- W71873315 hasConceptScore W71873315C97355855 @default.
- W71873315 hasLocation W718733151 @default.
- W71873315 hasOpenAccess W71873315 @default.
- W71873315 hasPrimaryLocation W718733151 @default.
- W71873315 hasRelatedWork W152281461 @default.
- W71873315 hasRelatedWork W1767169126 @default.
- W71873315 hasRelatedWork W1968649165 @default.
- W71873315 hasRelatedWork W1973637075 @default.
- W71873315 hasRelatedWork W1988609544 @default.
- W71873315 hasRelatedWork W2008475925 @default.
- W71873315 hasRelatedWork W2041716257 @default.
- W71873315 hasRelatedWork W2045262286 @default.
- W71873315 hasRelatedWork W2063655142 @default.
- W71873315 hasRelatedWork W2074172424 @default.
- W71873315 hasRelatedWork W2084771875 @default.
- W71873315 hasRelatedWork W2106750323 @default.
- W71873315 hasRelatedWork W2315476117 @default.
- W71873315 hasRelatedWork W2324232267 @default.
- W71873315 hasRelatedWork W2396724456 @default.
- W71873315 hasRelatedWork W2605743099 @default.
- W71873315 hasRelatedWork W2900519173 @default.
- W71873315 hasRelatedWork W2953622499 @default.
- W71873315 hasRelatedWork W3022319423 @default.
- W71873315 hasRelatedWork W2877877491 @default.
- W71873315 isParatext "false" @default.
- W71873315 isRetracted "false" @default.
- W71873315 magId "71873315" @default.
- W71873315 workType "dissertation" @default.