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- W71943386 abstract "Peanut and soy are both legumes and therefore phylogenetically related. Both peanutand soy should be addressed in the diagnostic work-up of a suspected allergy to eitherof these foods because of possible cross-reactivity. Allergic symptoms to both foodscan range from mild oral allergy symptoms to severe respiratory or even cardiovascularsymptoms. Therefore, it is important that peanut or soy allergy is not missed in thediagnostic procedure and an adequate elimination diet is prescribed. An incorrectdiagnosis of food allergy on the other hand significantly impairs the quality of life andincreases the risk of impaired growth and inadequate nutrient intake in case of children.Skin prick test (SPT) and IgE reactivity to peanut extract in serum are two methods thatare generally used to measure sensitization. Since sensitization is often not related toclinical symptoms, test results can be ‘false-positive’ when used as a diagnostic testfor peanut or soy allergy. The reference standard on the other hand, a double-blind,placebo-controlled food challenge, has many disadvantages: it is time-consuming,has high costs, is stressful for the patient, might result in severe clinical reactions andit requires highly dedicated hospital facilities. Therefore, there is strong need for anaccurate diagnostic test that is cheap, non-invasive and ideally can discriminate betweenmild and severe allergy as well. One possibility of improving diagnostics is by combiningseveral predictors into one prediction model. Another possibility is by measuring serumIgE (sIgE) to specific allergenic peanut proteins, also called components. At the moment,6 peanut components are commercially available and can therefore be used in clinicalpractice: Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, and Ara h 9. Their diagnostic accuracy canbe analyzed individually or in combination with each other or other clinical predictors.In Chapter 2 we systematically reviewed current literature for studies addressing thediagnostic accuracy of the current diagnostic tests (SPT and sIgE to peanut extract) ormeasuring sIgE to one or more peanut components in diagnosing peanut allergy. Alleligible studies were scored for risk of bias and concerns regarding applicability. Ourresults showed that sIgE to Ara h 2 had the best diagnostic accuracy of all diagnostic testmethods that were analyzed; it was best in both diagnosing as well as excluding peanutallergy, while SPT and sIgE to peanut extract were primarily useful in excluding peanutallergy." @default.
- W71943386 created "2016-06-24" @default.
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- W71943386 date "2014-09-26" @default.
- W71943386 modified "2023-09-27" @default.
- W71943386 title "Peanut allergy diagnosis and management: the role of allergen components" @default.
- W71943386 hasPublicationYear "2014" @default.
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