Matches in SemOpenAlex for { <https://semopenalex.org/work/W71947368> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W71947368 endingPage "178" @default.
- W71947368 startingPage "173" @default.
- W71947368 abstract "“Molecular signatures” or “gene-expression signatures” are a key feature in many studies that use microarray data in cancer research (e.g., Alizadeh et al., 2000; Golub et al., 1999; Pomeroy et al., 2002; Rosenwald et al., 2002; Shipp et al., 2002). Shaffer et al. (2001, p. 375) refer to signatures as“(...) genes that are coordinately expressed in samples related by some identifiable criterion such as cell type, differentiation state, or signaling response” (emphasis is ours). Molecular signatures are often used to model patients’ clinically relevant information (e.g., prognosis, survival time, etc) as a function of the gene expression data, but instead of using individual genes as predictors, the predictors are the signature components or “metagenes”. In spite of the widespread use of the term “molecular signature”, no explicit definition is available. Following the conventions of the literature, we will consider a signature to be composed of one or more signature components or metagenes, where each signature component is a weighted combination of one or more coexpressed genes, and such that statistical models that use signatures both have good predictive performance and are easy to interpret biologically. Based on the litearture, we can try to formalize these goals by requiring that signatures and signature components satisfy the following conditions:" @default.
- W71947368 created "2016-06-24" @default.
- W71947368 creator A5033483230 @default.
- W71947368 creator A5080620893 @default.
- W71947368 date "2004-01-01" @default.
- W71947368 modified "2023-10-17" @default.
- W71947368 title "Can we Find Molecular Signatures from Gene Expression Data" @default.
- W71947368 cites W1792175597 @default.
- W71947368 cites W1995945562 @default.
- W71947368 cites W2097879961 @default.
- W71947368 cites W2115709314 @default.
- W71947368 hasPublicationYear "2004" @default.
- W71947368 type Work @default.
- W71947368 sameAs 71947368 @default.
- W71947368 citedByCount "0" @default.
- W71947368 crossrefType "journal-article" @default.
- W71947368 hasAuthorship W71947368A5033483230 @default.
- W71947368 hasAuthorship W71947368A5080620893 @default.
- W71947368 hasConcept C104317684 @default.
- W71947368 hasConcept C121332964 @default.
- W71947368 hasConcept C124101348 @default.
- W71947368 hasConcept C14036430 @default.
- W71947368 hasConcept C150194340 @default.
- W71947368 hasConcept C168167062 @default.
- W71947368 hasConcept C18431079 @default.
- W71947368 hasConcept C199360897 @default.
- W71947368 hasConcept C2524010 @default.
- W71947368 hasConcept C2779696439 @default.
- W71947368 hasConcept C2779733811 @default.
- W71947368 hasConcept C33923547 @default.
- W71947368 hasConcept C41008148 @default.
- W71947368 hasConcept C54355233 @default.
- W71947368 hasConcept C70721500 @default.
- W71947368 hasConcept C8415881 @default.
- W71947368 hasConcept C86803240 @default.
- W71947368 hasConcept C90559484 @default.
- W71947368 hasConcept C97355855 @default.
- W71947368 hasConceptScore W71947368C104317684 @default.
- W71947368 hasConceptScore W71947368C121332964 @default.
- W71947368 hasConceptScore W71947368C124101348 @default.
- W71947368 hasConceptScore W71947368C14036430 @default.
- W71947368 hasConceptScore W71947368C150194340 @default.
- W71947368 hasConceptScore W71947368C168167062 @default.
- W71947368 hasConceptScore W71947368C18431079 @default.
- W71947368 hasConceptScore W71947368C199360897 @default.
- W71947368 hasConceptScore W71947368C2524010 @default.
- W71947368 hasConceptScore W71947368C2779696439 @default.
- W71947368 hasConceptScore W71947368C2779733811 @default.
- W71947368 hasConceptScore W71947368C33923547 @default.
- W71947368 hasConceptScore W71947368C41008148 @default.
- W71947368 hasConceptScore W71947368C54355233 @default.
- W71947368 hasConceptScore W71947368C70721500 @default.
- W71947368 hasConceptScore W71947368C8415881 @default.
- W71947368 hasConceptScore W71947368C86803240 @default.
- W71947368 hasConceptScore W71947368C90559484 @default.
- W71947368 hasConceptScore W71947368C97355855 @default.
- W71947368 hasOpenAccess W71947368 @default.
- W71947368 hasRelatedWork W1603641931 @default.
- W71947368 hasRelatedWork W1985563591 @default.
- W71947368 hasRelatedWork W1986203228 @default.
- W71947368 hasRelatedWork W2004850055 @default.
- W71947368 hasRelatedWork W2030052455 @default.
- W71947368 hasRelatedWork W2032065412 @default.
- W71947368 hasRelatedWork W2034595398 @default.
- W71947368 hasRelatedWork W2052811362 @default.
- W71947368 hasRelatedWork W2056489329 @default.
- W71947368 hasRelatedWork W2102999073 @default.
- W71947368 hasRelatedWork W2111576144 @default.
- W71947368 hasRelatedWork W2112012611 @default.
- W71947368 hasRelatedWork W2125256388 @default.
- W71947368 hasRelatedWork W2131610601 @default.
- W71947368 hasRelatedWork W2137350216 @default.
- W71947368 hasRelatedWork W2150926065 @default.
- W71947368 hasRelatedWork W2164891186 @default.
- W71947368 hasRelatedWork W2186769805 @default.
- W71947368 hasRelatedWork W2584379409 @default.
- W71947368 hasRelatedWork W2736220467 @default.
- W71947368 isParatext "false" @default.
- W71947368 isRetracted "false" @default.
- W71947368 magId "71947368" @default.
- W71947368 workType "article" @default.