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- W72012808 abstract "Este estudo trata do envolvimento dos neutrofilos, granulocitos polimorfonucleares, no estabelecimento da infeccao pelos parasitos do genero Leishmania. Embora tais leucocitos sejam considerados a primeira linha de defesa do sistema imune inato do organismo contra agentes patogenicos, estudos tem indicado a participacao do mesmo como veiculo de disseminacao dos parasitos Leishmania major no organismo hospedeiro. Por outro lado, estudos envolvendo os parasitos Leishmania donovani e/ou Leishmania infantum/chagasi tem demonstrado o papel protetor destas celulas, contrariando a hipotese do “Cavalo de Troia” postulada para o modelo de infeccao por Leishmania major. Pretende-se, portanto, discutir brevemente, atraves de uma revisao sistematica da literatura, o papel dubio dos neutrofilos na infeccao por parasitos causadores das leishmanioses. THE DUAL ROLE OF NEUTROPHILS IN THE INFECTION BY PARASITES OF Leishmania GENUS: A BRIEF DISCUSSION This study deals with the involvement of neutrophils, polymorphonuclear granulocytes, in the establishment of the infection by parasites of the Leishmania genus. Although such leukocytes are considered the first line of defense of the innate immune system against pathogenic agents, studies have shown their participation as means of dissemination of the parasites Leishmania major in host organism. On the other hand, studies involving the parasites Leishmania donovani and/or Leishmania infantum/chagasi have shown the protective role of these cells, contradicting the Trojan Horse hypothesis assumed for the Leishmania major infection model. It is intended, therefore, to discuss briefly, through a systematic revision of literature, the dual role of the neutrophils in the infection by parasites which cause leishmaniasis." @default.
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- W72012808 date "2009-07-28" @default.
- W72012808 modified "2023-09-23" @default.
- W72012808 title "O PAPEL DÚBIO DOS NEUTRÓFILOS NA INFECÇÃO POR PARASITOS DO GÊNERO Leishmania: UMA BREVE DISCUSSÃO" @default.
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