Matches in SemOpenAlex for { <https://semopenalex.org/work/W7203767> ?p ?o ?g. }
- W7203767 abstract "Development of the fundamental and clinical «regenerative medicine» is based on the progress of gene, stem cell and gene-cell biotechnologies. However, the reliable preclinical investigations on animal models and more over clinical trials stay far away from the available nowadays gene and cell constructions. Neuroscience is one of the fast growing fields of knowledge in biology and medicine. Pioneer experiments in neuroscience promises breakthrough in the innovative methods for treatment of neurodegenerative diseases in near future. This review addresses strategies for gene-cell therapy of neurodegenerative diseases by the example of amyotrophic lateral sclerosis. Precisely gene modification of mononuclear fraction of umbilical cord blood cells (UCBC) by dual cassette plasmid vectors is observed. Based on our own results of transplantation of genetically modified UCBC overexpressing recombinant neural cell adhesion molecule L1, vascular endothelial growth factor, fibroblast growth factor 2, and glial derived neurotrophic factor in different combinations we provide the experimental data for usefulness of transplantation of gene modified UCBC for treating neurodegenerative diseases. In the review we discuss the efficacy of gene modification of UCBC not only for secretion of recombinant proteins, but in increasing of transplanted cells survivability, their migration possibilities and capability to differentiate in endothelial, microglial and macroglial cell types." @default.
- W7203767 created "2016-06-24" @default.
- W7203767 creator A5045575672 @default.
- W7203767 creator A5066414193 @default.
- W7203767 creator A5067392257 @default.
- W7203767 creator A5069048701 @default.
- W7203767 creator A5073828136 @default.
- W7203767 creator A5091529063 @default.
- W7203767 date "2012-01-01" @default.
- W7203767 modified "2023-09-27" @default.
- W7203767 title "Доклинические исследования терапии бокового амиотрофического склероза с помощью генетически модифицированных мононуклеарных клеток крови пуповины" @default.
- W7203767 cites W1894493322 @default.
- W7203767 cites W1964623184 @default.
- W7203767 cites W1978320551 @default.
- W7203767 cites W1979456879 @default.
- W7203767 cites W1985460018 @default.
- W7203767 cites W1987308004 @default.
- W7203767 cites W1998413748 @default.
- W7203767 cites W2005808616 @default.
- W7203767 cites W2009498071 @default.
- W7203767 cites W2014386715 @default.
- W7203767 cites W2017195491 @default.
- W7203767 cites W2024009556 @default.
- W7203767 cites W2031493981 @default.
- W7203767 cites W2032145250 @default.
- W7203767 cites W2032625959 @default.
- W7203767 cites W2034167745 @default.
- W7203767 cites W2042482088 @default.
- W7203767 cites W2047263029 @default.
- W7203767 cites W2049995657 @default.
- W7203767 cites W2053272214 @default.
- W7203767 cites W2056372586 @default.
- W7203767 cites W2057994916 @default.
- W7203767 cites W2074238578 @default.
- W7203767 cites W2079870118 @default.
- W7203767 cites W2091153543 @default.
- W7203767 cites W2091741117 @default.
- W7203767 cites W2107768418 @default.
- W7203767 cites W2112444654 @default.
- W7203767 cites W2118197922 @default.
- W7203767 cites W2121396070 @default.
- W7203767 cites W2125619731 @default.
- W7203767 cites W2126229173 @default.
- W7203767 cites W2129411138 @default.
- W7203767 cites W2129781842 @default.
- W7203767 cites W2133481870 @default.
- W7203767 cites W2133811999 @default.
- W7203767 cites W2139208934 @default.
- W7203767 cites W2141570423 @default.
- W7203767 cites W2154104720 @default.
- W7203767 cites W2161315339 @default.
- W7203767 cites W2166450763 @default.
- W7203767 cites W2171634890 @default.
- W7203767 cites W2318530450 @default.
- W7203767 hasPublicationYear "2012" @default.
- W7203767 type Work @default.
- W7203767 sameAs 7203767 @default.
- W7203767 citedByCount "0" @default.
- W7203767 crossrefType "journal-article" @default.
- W7203767 hasAuthorship W7203767A5045575672 @default.
- W7203767 hasAuthorship W7203767A5066414193 @default.
- W7203767 hasAuthorship W7203767A5067392257 @default.
- W7203767 hasAuthorship W7203767A5069048701 @default.
- W7203767 hasAuthorship W7203767A5073828136 @default.
- W7203767 hasAuthorship W7203767A5091529063 @default.
- W7203767 hasConcept C104317684 @default.
- W7203767 hasConcept C10854531 @default.
- W7203767 hasConcept C111599444 @default.
- W7203767 hasConcept C126322002 @default.
- W7203767 hasConcept C160539049 @default.
- W7203767 hasConcept C167734588 @default.
- W7203767 hasConcept C169760540 @default.
- W7203767 hasConcept C170493617 @default.
- W7203767 hasConcept C203014093 @default.
- W7203767 hasConcept C2775960820 @default.
- W7203767 hasConcept C2777025900 @default.
- W7203767 hasConcept C28328180 @default.
- W7203767 hasConcept C2911091166 @default.
- W7203767 hasConcept C502942594 @default.
- W7203767 hasConcept C54355233 @default.
- W7203767 hasConcept C71924100 @default.
- W7203767 hasConcept C86803240 @default.
- W7203767 hasConcept C95444343 @default.
- W7203767 hasConceptScore W7203767C104317684 @default.
- W7203767 hasConceptScore W7203767C10854531 @default.
- W7203767 hasConceptScore W7203767C111599444 @default.
- W7203767 hasConceptScore W7203767C126322002 @default.
- W7203767 hasConceptScore W7203767C160539049 @default.
- W7203767 hasConceptScore W7203767C167734588 @default.
- W7203767 hasConceptScore W7203767C169760540 @default.
- W7203767 hasConceptScore W7203767C170493617 @default.
- W7203767 hasConceptScore W7203767C203014093 @default.
- W7203767 hasConceptScore W7203767C2775960820 @default.
- W7203767 hasConceptScore W7203767C2777025900 @default.
- W7203767 hasConceptScore W7203767C28328180 @default.
- W7203767 hasConceptScore W7203767C2911091166 @default.
- W7203767 hasConceptScore W7203767C502942594 @default.
- W7203767 hasConceptScore W7203767C54355233 @default.
- W7203767 hasConceptScore W7203767C71924100 @default.
- W7203767 hasConceptScore W7203767C86803240 @default.