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- W72065072 abstract "The increasing bacterial resistance to antibiotics and the growing interest in human health have resultedinto an increasing need for the exploration of both the essential oils and other plant extracts in the food andpharmaceutical industries. This work, as part of on-going work on the leaves of Nahar (Mesua ferrea) plant,was aimed at evaluating the antibacterial activity, minimum inhibitory concentration as well as the cytotoxicityof the leaves extract. The dry leaves were grinded and extracted in an oven shaker set at 37°C and 200rpm for24 hours using ethanol and methanol as solvents. The agar disc diffusion method was used for the evaluation ofantibacterial property of the leaves extract, micro broth dilution was employed for the determination ofminimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), while Brine shrimp(Artemia salina) lethality bioassay was made use of for the cytotoxicity assay. Ethanol gave higher extract’syield (6.20%) than methanol. The extract showed a remarkable antibacterial property against all the selectedmicrobes (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus) with theinhibition zones ranging from 16.0±0.5 mm to 18.0±0.5 mm for all the tested bacteria. The MIC range of 2.5-0.625 mg/mL with MBC value of 5 mg/mL was obtained for the gram-negative bacteria while MIC range of1.3- 0.313 mg/mL with MBC value of 2.5 mg/mL was obtained for the gram-positive bacteria. The leavesextract was found to be toxic to the Brine shrimps with LC50 of 500ppm (μg/mL) suggesting that the extractsmay contain bioactive compounds of potential therapeutic and prophylactic significance" @default.
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- W72065072 date "2012-01-01" @default.
- W72065072 modified "2023-09-28" @default.
- W72065072 title "Anti-bacterial and cytotoxicity properties of the leaves extract of nahar (Mesua Ferrea) plant" @default.
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