Matches in SemOpenAlex for { <https://semopenalex.org/work/W72090187> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W72090187 endingPage "45.4" @default.
- W72090187 startingPage "45.4" @default.
- W72090187 abstract "Abstract CD22 and SiglecG are proposed to be negative regulators of B cell receptor signaling through their ability to recognize sialic acid-containing glycans. Recent studies have shown that multivalent presentation of high affinity CD22 and SiglecG ligands in cis with a T-independent antigen can tolerize B cells (Duong et al., J. Exp. Med., 2010). Here we describe studies aimed at showing the generality of this phenomenon. To realize this aim, a novel liposomal nanoparticle platform was developed for presentation of both high affinity Siglec ligands and antigen. Chemical conjugation of the Siglec ligand and antigen to this platform is facile and, importantly, this platform is highly compatible with in vivo studies. Using this new platform, robust B cell tolerance is achieved toward both T-independent and T-dependent antigens in mice. Mechanistic studies provide clear evidence that: i) CD22 and SiglecG are the targets; ii) apoptosis of B cells is the mode of tolerance; iii) tolerization is highly selective to B cells containing a BCR that is specific for the targeted antigen. These studies reinforce the hypothesis that CD22 and SiglecG are critical components of a B cell that allows it to distinguish self from non-self. This method has clear potential for treatment of autoimmune diseases and allergies by antigen specific tolerization of B cells." @default.
- W72090187 created "2016-06-24" @default.
- W72090187 creator A5020693561 @default.
- W72090187 creator A5039824850 @default.
- W72090187 creator A5087354201 @default.
- W72090187 date "2011-04-01" @default.
- W72090187 modified "2023-09-25" @default.
- W72090187 title "Induction of antigen-specific B cell tolerance through the development of a versatile platform to target siglecs (45.4)" @default.
- W72090187 doi "https://doi.org/10.4049/jimmunol.186.supp.45.4" @default.
- W72090187 hasPublicationYear "2011" @default.
- W72090187 type Work @default.
- W72090187 sameAs 72090187 @default.
- W72090187 citedByCount "0" @default.
- W72090187 crossrefType "journal-article" @default.
- W72090187 hasAuthorship W72090187A5020693561 @default.
- W72090187 hasAuthorship W72090187A5039824850 @default.
- W72090187 hasAuthorship W72090187A5087354201 @default.
- W72090187 hasConcept C111700020 @default.
- W72090187 hasConcept C147483822 @default.
- W72090187 hasConcept C157695867 @default.
- W72090187 hasConcept C159654299 @default.
- W72090187 hasConcept C185592680 @default.
- W72090187 hasConcept C203014093 @default.
- W72090187 hasConcept C2776090121 @default.
- W72090187 hasConcept C2778017598 @default.
- W72090187 hasConcept C2778453870 @default.
- W72090187 hasConcept C2780115458 @default.
- W72090187 hasConcept C55493867 @default.
- W72090187 hasConcept C83464605 @default.
- W72090187 hasConcept C86803240 @default.
- W72090187 hasConcept C8891405 @default.
- W72090187 hasConcept C95444343 @default.
- W72090187 hasConceptScore W72090187C111700020 @default.
- W72090187 hasConceptScore W72090187C147483822 @default.
- W72090187 hasConceptScore W72090187C157695867 @default.
- W72090187 hasConceptScore W72090187C159654299 @default.
- W72090187 hasConceptScore W72090187C185592680 @default.
- W72090187 hasConceptScore W72090187C203014093 @default.
- W72090187 hasConceptScore W72090187C2776090121 @default.
- W72090187 hasConceptScore W72090187C2778017598 @default.
- W72090187 hasConceptScore W72090187C2778453870 @default.
- W72090187 hasConceptScore W72090187C2780115458 @default.
- W72090187 hasConceptScore W72090187C55493867 @default.
- W72090187 hasConceptScore W72090187C83464605 @default.
- W72090187 hasConceptScore W72090187C86803240 @default.
- W72090187 hasConceptScore W72090187C8891405 @default.
- W72090187 hasConceptScore W72090187C95444343 @default.
- W72090187 hasIssue "1_Supplement" @default.
- W72090187 hasLocation W720901871 @default.
- W72090187 hasOpenAccess W72090187 @default.
- W72090187 hasPrimaryLocation W720901871 @default.
- W72090187 hasRelatedWork W129254516 @default.
- W72090187 hasRelatedWork W2025086964 @default.
- W72090187 hasRelatedWork W2033799256 @default.
- W72090187 hasRelatedWork W2115414456 @default.
- W72090187 hasRelatedWork W2116734756 @default.
- W72090187 hasRelatedWork W2122468690 @default.
- W72090187 hasRelatedWork W2167890843 @default.
- W72090187 hasRelatedWork W2332513933 @default.
- W72090187 hasRelatedWork W2778153959 @default.
- W72090187 hasRelatedWork W2888640753 @default.
- W72090187 hasVolume "186" @default.
- W72090187 isParatext "false" @default.
- W72090187 isRetracted "false" @default.
- W72090187 magId "72090187" @default.
- W72090187 workType "article" @default.