Matches in SemOpenAlex for { <https://semopenalex.org/work/W72147436> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W72147436 endingPage "91" @default.
- W72147436 startingPage "486" @default.
- W72147436 abstract "Therapy of detrusor hyperactivity with anticholinergic agents often is followed by adverse drug reactions. Intravesical application may be an interesting alternative. A randomised, single-blind, placebo-controlled, mono-centre clinical trial was carried out in 84 patients with urgency or urge incontinence. Due to intravesical administration of oxybutynin (CAS 5633-20-5) (n = 21) and trospium chloride (CAS 10405-02-4) (n = 21), respectively, a significant increase in maximum bladder capacity and decrease of detrusor pressure accompanied by an increase of residual urine were found in comparison to placebo in urodynamical investigations. Improvement of uninhibited bladder contractions occurred leading to higher filling volume. Under verapamil (CAS 152-11-4) (n = 21) no marked changes in the efficacy variables were found compared with placebo. All patients completed the study and were assessed with regard to efficacy and safety. No adverse events or marked changes in the vital signs were reported. The immediate onset of effect and the lack of adverse drug reactions suggest that treatment with topical oxybutynin or trospium chloride is an effective alternative in patients with intolerable side effects when orally treated. In addition, intravesical administration may be indicated in patients with bladder spasms due to indwelling catheter or in order to increase bladder capacity before percutaneous cystostomy." @default.
- W72147436 created "2016-06-24" @default.
- W72147436 creator A5018398178 @default.
- W72147436 creator A5049538028 @default.
- W72147436 creator A5067781106 @default.
- W72147436 creator A5078270210 @default.
- W72147436 date "1998-05-01" @default.
- W72147436 modified "2023-09-26" @default.
- W72147436 title "[Intravesical instillation of trospium chloride, oxybutynin and verapamil for relaxation of the bladder detrusor muscle. A placebo controlled, randomized clinical test]." @default.
- W72147436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9638316" @default.
- W72147436 hasPublicationYear "1998" @default.
- W72147436 type Work @default.
- W72147436 sameAs 72147436 @default.
- W72147436 citedByCount "9" @default.
- W72147436 countsByYear W721474362012 @default.
- W72147436 crossrefType "journal-article" @default.
- W72147436 hasAuthorship W72147436A5018398178 @default.
- W72147436 hasAuthorship W72147436A5049538028 @default.
- W72147436 hasAuthorship W72147436A5067781106 @default.
- W72147436 hasAuthorship W72147436A5078270210 @default.
- W72147436 hasConcept C126322002 @default.
- W72147436 hasConcept C126894567 @default.
- W72147436 hasConcept C142724271 @default.
- W72147436 hasConcept C197934379 @default.
- W72147436 hasConcept C204787440 @default.
- W72147436 hasConcept C27081682 @default.
- W72147436 hasConcept C2777844464 @default.
- W72147436 hasConcept C2778689640 @default.
- W72147436 hasConcept C2778941218 @default.
- W72147436 hasConcept C2779762690 @default.
- W72147436 hasConcept C2780616540 @default.
- W72147436 hasConcept C2781020410 @default.
- W72147436 hasConcept C2910745098 @default.
- W72147436 hasConcept C42219234 @default.
- W72147436 hasConcept C71924100 @default.
- W72147436 hasConceptScore W72147436C126322002 @default.
- W72147436 hasConceptScore W72147436C126894567 @default.
- W72147436 hasConceptScore W72147436C142724271 @default.
- W72147436 hasConceptScore W72147436C197934379 @default.
- W72147436 hasConceptScore W72147436C204787440 @default.
- W72147436 hasConceptScore W72147436C27081682 @default.
- W72147436 hasConceptScore W72147436C2777844464 @default.
- W72147436 hasConceptScore W72147436C2778689640 @default.
- W72147436 hasConceptScore W72147436C2778941218 @default.
- W72147436 hasConceptScore W72147436C2779762690 @default.
- W72147436 hasConceptScore W72147436C2780616540 @default.
- W72147436 hasConceptScore W72147436C2781020410 @default.
- W72147436 hasConceptScore W72147436C2910745098 @default.
- W72147436 hasConceptScore W72147436C42219234 @default.
- W72147436 hasConceptScore W72147436C71924100 @default.
- W72147436 hasIssue "5" @default.
- W72147436 hasLocation W721474361 @default.
- W72147436 hasOpenAccess W72147436 @default.
- W72147436 hasPrimaryLocation W721474361 @default.
- W72147436 hasRelatedWork W134550863 @default.
- W72147436 hasRelatedWork W1542102176 @default.
- W72147436 hasRelatedWork W1986053715 @default.
- W72147436 hasRelatedWork W2014110087 @default.
- W72147436 hasRelatedWork W2055803098 @default.
- W72147436 hasRelatedWork W2120154075 @default.
- W72147436 hasRelatedWork W2124954720 @default.
- W72147436 hasRelatedWork W2341457268 @default.
- W72147436 hasRelatedWork W2443843006 @default.
- W72147436 hasRelatedWork W72147436 @default.
- W72147436 hasVolume "48" @default.
- W72147436 isParatext "false" @default.
- W72147436 isRetracted "false" @default.
- W72147436 magId "72147436" @default.
- W72147436 workType "article" @default.