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- W72149043 abstract "Grape seed extract (GSE) has been proven to inhibit cell proliferation and induce apoptosis in various human carcinoma cell lines. Herein, we evaluated the in vitro antiproliferative and apoptotic effects of GSE against colon cancer cell line HCT116. The cytotoxic effect of GSE was examined on human colon cancer HCT116 and normal WISH cells. In addition, we evaluated the antiproliferative and apoptotic effects of different concentrations of GSE (25, 50 and 100μg/ml) at different sampling time (24, 48, 72 and 96hrs) on HCT116 cells using cell proliferation and DNA fragmentation assays respectively. Because the p53 tumor suppressor protein plays an important role in cellular proliferation and apoptosis, we examined p53 mRNAs expression in relation with BAX and BCL-2 mRNAs expression. The present study revealed that GSE did not suppress the proliferation of normal human WISH cells, while, GSE suppressed proliferation and induced apoptosis in human HCT116 colon cancer cells indicating that GSE preferentially target cancer cells while sparing their normal counterparts. GSE exerts its effect on HCT116 cell line via p53, BAX upregulation and BCL-2 downregulation especially at 72-96hrs in a dose-dependent manner. Taken together, our findings suggest that GSE could be an effective complementary medicine agent against colorectal cancer possibly due to its strong growth inhibitory and apoptosis inducing effects." @default.
- W72149043 created "2016-06-24" @default.
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- W72149043 date "2013-07-01" @default.
- W72149043 modified "2023-09-24" @default.
- W72149043 title "Antiproliferative and apoptotic effects of grape seed extract on human colon cancer cell line HCT116." @default.
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