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- W72186710 endingPage "lxxxix" @default.
- W72186710 startingPage "lxxi" @default.
- W72186710 abstract "Observational studies of drug effects are often regarded as inadequate in providing evidence of benefits but accepted as evidence of harms. Important harms that have been suggested by observational studies include teratogenicity of selective serotonin reuptake inhibitors, suicide associated with isotretinoin, and asthma associated with paracetamol. However, in all these cases the evidence is highly variable, and factors such as confounding by indication or selection bias have not been adequately taken into account. Systematic reviews of studies that are subject to confounding are themselves similarly affected. Other examples of drug-event pairs highlighted by observational studies include glucocorticoids and atrial fibrillation, antipsychotic drugs and raised hemoglobin A1C, adverse reactions to proton pump inhibitors plus clopidogrel, psychoactive drugs and memory loss, and adverse reactions to methylphenidate. We should not jump to the conclusion that causation is implied when an event has been attributed to a medication in an observational study, unless the odds ratio is very high or the study has been designed so as to eliminate or at least reduce the likelihood of such factors as confounding and selection bias; whenever possible, studies of adverse drug reactions should be so designed from the start. Furthermore, when adverse reactions are listed in information sources, such as Summaries of Product Characteristics, the level of evidence on which they are based should be stated. If the evidence falls short of proof of an association, it may be appropriate to issue a precautionary warning, making it clear that the association has not been proven." @default.
- W72186710 created "2016-06-24" @default.
- W72186710 creator A5081151451 @default.
- W72186710 date "2014-01-01" @default.
- W72186710 modified "2023-10-04" @default.
- W72186710 title "Side effects of drugs essay" @default.
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