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• W72212302 abstract "Abstract Microbial products including mycobacterial antigens are recognized by distinct Toll like receptors (TLR) resulting in activation of cells of the innate immune system. Several mycobacterial components such lipomannan have been identified with dual functions -activating antigen presenting cells via TLR2 and inhibiting TLR activation pathways in a TLR independent way. Ablation of TLR signalling as described for mice deficient for the common adaptor protein MyD88 revealed that TLRs are crucial for the activation of an innate immune response as MyD88 deficient mice are highly sensitive to infection with Mycobacterium tuberculosis . Despite the profound defect of the innate immune response, MyD88 deficiency allows the emergence of an adaptive immunity. These data demonstrate that activation of multiple TLRs contributes to an efficient innate response to mycobacteria, while MyD88-dependent signalling is dispensable to generate adaptive immunity. Background: Tuberculosis, immune response and Toll-Like receptors" @default.
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• W72212302 date "2006-01-01" @default.
• W72212302 modified "2023-10-18" @default.
• W72212302 title "ROLE OF TOLL-LIKE RECEPTORS SENSING AND CONTROL OFMYCOBACTERIAL INFECTION" @default.
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