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- W72260913 abstract "Pentachloroanisole (PCA), an environmental degradation product of the biocide pentachlorophenol (PCP), has been detected in the food chain. The metabolic fate of PCA was examined in miniature pig hepatic microsomes, in vitro. The compound was shown to be a substrate for a cytochrome P450-dependent demethylation reaction, which results in the regeneration of the parent compound, PCP. A disproportionately large increase in PCA demethylase activity (PCADM) following pretreatment with phenobarbital suggests that the compound is preferentially metabolized by specific-inducible form(s) of cytochrome P450." @default.
- W72260913 created "2016-06-24" @default.
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- W72260913 date "2020-05-26" @default.
- W72260913 modified "2023-10-14" @default.
- W72260913 title "Age Related Changes in the Induction of Hepatic Mixed-Function Monooxygenase System in Miniature Pigs: Effects of Pentachloroanisole, Pentachlorophenol and Phenobarbital" @default.
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- W72260913 doi "https://doi.org/10.23860/diss-agins-alan-1982" @default.
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