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- W7231415 endingPage "443" @default.
- W7231415 startingPage "407" @default.
- W7231415 abstract "This chapter reviews homogeneous antibodies and myeloma proteins with antibody activity. Homogeneous proteins with antibody activity have a major practical use in the study of the relationship of amino acid sequence and 3-dimensional structure of an antibody to its specificity. It is generally accepted that homogeneous antibody populations and myeloma proteins are synthesized by individual clones of cells that have undergone extensive proliferation, frequently at the expense of the biosynthesis of other immunoglobulins. In the case of antibodies to bacterial vaccines induced in experimental animals, the antibody concentration in serum often exceeds the total concentration of immunoglobulin in normal, non-immunized animals. This concentration relationship also applies to myeloma proteins. Continuous immunization is necessary to maintain a high concentration of homogeneous antibody; and, in the face of repeated challenge by antigen, clones producing homogeneous antibody may on occasion diminish and be replaced by other clones of cells manufacturing antibody differing in structure but having specificity for the same antigen." @default.
- W7231415 created "2016-06-24" @default.
- W7231415 creator A5025097601 @default.
- W7231415 creator A5041745642 @default.
- W7231415 creator A5076137252 @default.
- W7231415 date "1975-01-01" @default.
- W7231415 modified "2023-10-18" @default.
- W7231415 title "Homogeneous Antibodies and Myeloma Proteins with Antibody Activity" @default.
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