Matches in SemOpenAlex for { <https://semopenalex.org/work/W72373556> ?p ?o ?g. }
- W72373556 endingPage "1128" @default.
- W72373556 startingPage "1118" @default.
- W72373556 abstract "Gliomas with hybrid oligodendroglial/astrocytic features are diagnostically problematic, and our ability to predict tumor behavior is limited. Some likely represent intermingled mixed oligoastrocytomas (MOAs), though precise diagnostic criteria and specific markers for this lesion are lacking. From the files at Washington University (1987-2000), 155 ambiguous glioma/intermingled MOA candidates were independently classified and graded by 5 neuropathologists, with consensus-derived pure oligodendrogliomas and astrocytomas excluded from further study. The 90 remaining cases (grades II = 29, III = 44, IV = 17) were analyzed by FISH on formalin-fixed, paraffin-embedded sections. Detectable deletions included combined 1p/19q (9%), solitary 19q (22%), PTEN/DMBT1 (26%), and p16 (32%). EGFR amplification was found in 11%. Patients were followed until death (47%) or a median of 3.3 years. Similar to prior glioma series, patient age (p < 0.0001) and tumor grade (p < 0.0001) were strongly associated with survival times. EGFR amplification (p = 0.0007) and deletions of PTEN/ DMBT1 (p = 0.016) or p16 (p = 0.014), either individually or as a group (p = 0.04), portended a shorter median survival compared with tumors lacking these alterations. We conclude that 1) distinct genetic subsets are identifiable by FISH in morphologically ambiguous gliomas, and 2) both histological grading and molecular analysis yield prognostically useful information." @default.
- W72373556 created "2016-06-24" @default.
- W72373556 creator A5011661289 @default.
- W72373556 creator A5013907641 @default.
- W72373556 creator A5026609192 @default.
- W72373556 creator A5038758595 @default.
- W72373556 creator A5048989612 @default.
- W72373556 creator A5049749614 @default.
- W72373556 creator A5052983963 @default.
- W72373556 creator A5066680514 @default.
- W72373556 creator A5067993987 @default.
- W72373556 date "2003-11-01" @default.
- W72373556 modified "2023-09-23" @default.
- W72373556 title "Clinical Utility of Fluorescence In Situ Hybridization (FISH) in Morphologically Ambiguous Gliomas with Hybrid Oligodendroglial/Astrocytic Features" @default.
- W72373556 cites W1966066582 @default.
- W72373556 cites W1968466970 @default.
- W72373556 cites W1970538552 @default.
- W72373556 cites W1972705864 @default.
- W72373556 cites W1975287918 @default.
- W72373556 cites W1978503339 @default.
- W72373556 cites W1985948370 @default.
- W72373556 cites W2001493754 @default.
- W72373556 cites W2003641752 @default.
- W72373556 cites W2012768021 @default.
- W72373556 cites W2016086666 @default.
- W72373556 cites W2019189562 @default.
- W72373556 cites W2029764040 @default.
- W72373556 cites W2033914302 @default.
- W72373556 cites W2037103584 @default.
- W72373556 cites W2045877981 @default.
- W72373556 cites W2046669349 @default.
- W72373556 cites W2046796218 @default.
- W72373556 cites W2047319598 @default.
- W72373556 cites W2051686152 @default.
- W72373556 cites W2069059931 @default.
- W72373556 cites W2075554829 @default.
- W72373556 cites W2082994442 @default.
- W72373556 cites W2092029005 @default.
- W72373556 cites W2093014822 @default.
- W72373556 cites W2129768320 @default.
- W72373556 cites W2141035496 @default.
- W72373556 cites W2141431050 @default.
- W72373556 cites W2143739956 @default.
- W72373556 cites W2166708153 @default.
- W72373556 cites W2168298750 @default.
- W72373556 cites W2168908657 @default.
- W72373556 cites W2312487041 @default.
- W72373556 cites W25246009 @default.
- W72373556 cites W263019299 @default.
- W72373556 cites W339986449 @default.
- W72373556 cites W3625525 @default.
- W72373556 cites W4255080289 @default.
- W72373556 cites W81665236 @default.
- W72373556 doi "https://doi.org/10.1093/jnen/62.11.1118" @default.
- W72373556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14656070" @default.
- W72373556 hasPublicationYear "2003" @default.
- W72373556 type Work @default.
- W72373556 sameAs 72373556 @default.
- W72373556 citedByCount "102" @default.
- W72373556 countsByYear W723735562012 @default.
- W72373556 countsByYear W723735562013 @default.
- W72373556 countsByYear W723735562014 @default.
- W72373556 countsByYear W723735562015 @default.
- W72373556 countsByYear W723735562016 @default.
- W72373556 countsByYear W723735562017 @default.
- W72373556 countsByYear W723735562018 @default.
- W72373556 countsByYear W723735562019 @default.
- W72373556 countsByYear W723735562020 @default.
- W72373556 countsByYear W723735562021 @default.
- W72373556 countsByYear W723735562022 @default.
- W72373556 crossrefType "journal-article" @default.
- W72373556 hasAuthorship W72373556A5011661289 @default.
- W72373556 hasAuthorship W72373556A5013907641 @default.
- W72373556 hasAuthorship W72373556A5026609192 @default.
- W72373556 hasAuthorship W72373556A5038758595 @default.
- W72373556 hasAuthorship W72373556A5048989612 @default.
- W72373556 hasAuthorship W72373556A5049749614 @default.
- W72373556 hasAuthorship W72373556A5052983963 @default.
- W72373556 hasAuthorship W72373556A5066680514 @default.
- W72373556 hasAuthorship W72373556A5067993987 @default.
- W72373556 hasBestOaLocation W723735561 @default.
- W72373556 hasConcept C104317684 @default.
- W72373556 hasConcept C142724271 @default.
- W72373556 hasConcept C143998085 @default.
- W72373556 hasConcept C150194340 @default.
- W72373556 hasConcept C18903297 @default.
- W72373556 hasConcept C190283241 @default.
- W72373556 hasConcept C2777286243 @default.
- W72373556 hasConcept C2777542201 @default.
- W72373556 hasConcept C2777609662 @default.
- W72373556 hasConcept C2777931997 @default.
- W72373556 hasConcept C2778227246 @default.
- W72373556 hasConcept C2778880634 @default.
- W72373556 hasConcept C2909208804 @default.
- W72373556 hasConcept C2910969760 @default.
- W72373556 hasConcept C30481170 @default.
- W72373556 hasConcept C502942594 @default.
- W72373556 hasConcept C505870484 @default.