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- W72377264 abstract "Introduction: Late postoperative hypoxaemia is common after major surgery, and may be a contributing factor leading to complications. Procedures to identify and monitor the pulmonary abnormalities leading to hypoxaemia range from the use of multicompartmental models and tracers to the estimate of a single effective shunt parameter. We have studied hypoxaemia following coronary artery bypass surgery (CABG) and gynecological laparotomy, and estimated two parameters of a mathematical model of oxygen transport (1) describing pulmonary dysfunction, pulmonary shunt (shunt) and alveolar lung capillary diffusion resistance (Rdiff). Methods: Patients undergoing CABG surgery were studied 2-4 hours, one, two and seven days after surgery. Patients scheduled for gynecological laparotomy were studied the day before surgery and 2, 8 and 48 hours postoperatively. On each occasion inspired oxygen fraction (FIO2) was varied in 4 to 6 steps in order to achieve oxygen saturations (SaO2) in the range of 90 to 100%. Measurements were taken at each inspired oxygen fraction and included: minute volume, respiratory frequency, arterial oxygen saturation (blood samples or pulse oximetry) and end-tidal gases.These measurements were used to estimate shunt and Rdiff. Results: Figure 1 Figure 2. Figures 1 and 2 illustrate end tidal oxygen fraction plotted against SaO2 and model fitted curves to these data from one patient HAB 2 (o) and 7 (*) days after CABG (fig. 1), and from one patient IBL before and 8 hours after hysterectomy (fig. 2). For the CABG patient oxygenation is improved from day 2 to day 7. This is illustrated as a shift of the FEO2/SaO2 curve to the left. The FEO2/SaO2 curves for the hysterectomy patient illustrates the effects of surgery upon oxygenation, i.e. the curve is shifted to the right postoperatively. These lateral displacements of the FEO2/SaO2 can be quantified by changes in Rdiff. +" @default.
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- W72377264 date "1999-01-01" @default.
- W72377264 modified "2023-09-27" @default.
- W72377264 title "Using a mathematical model of oxygen transport to monitor pulmonary function following surgery" @default.
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