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- W72425244 abstract "Portal hypertension increases splenic venous outflow pressure, and triggers a splenorenal reflex reduction in renal blood flow (RBF). Previous studies suggest that mesenteric vascular outflow pressure, which rises in portal hypertension, may also influence renal function. We investigated the role of the intestine in modulating RBF. We reasoned that whereas occlusion of the portal vein rostral to the porto-splenic junction would raise both mesenteric and intrasplenic pressure, thus initiating the splenorenal reflex and reducing RBF, occlusion caudal to the porto-splenic junction would increase only mesenteric venous outflow pressure. Any change in renal sympathetic nerve activity could then be attributed to an intestinal/renal reflex arc. We measured splenic afferent and renal efferent nerve activity during portal vein occlusion. There was no difference in the rise in portal venous pressure when the portal vein was partially occluded rostral or caudal to the porto-splenic junction (6.5 ± 0.2 to 14.6 ± 0.4 mmHg, n= 23). However, whereas rostral occlusion caused an increase in both splenic afferent (9.5 ± 2.1 to 14.7 ± 2.2 spikes/ sec, n=7) and renal efferent (9.1 ± 1.5 to 13.9 ± 3.0 spikes/sec, n=5) nerve activity, there were no such changes during caudal occlusion (Splenic Afferent: 9.3 ± 0.9 to 7.3 ± 1.5 spikes/sec, n= 6; Renal Efferent: 8.2 ± 2.2 to 5.0 ± 1.1 spikes/sec, n=5). In conclusion, the selective increase in mesenteric venous outflow pressure did not alter renal sympathetic nerve activity. We therefore found no evidence for intestinal-renal reflex control of renal function during portal hypertension (HSFC, CIHR)." @default.
- W72425244 created "2016-06-24" @default.
- W72425244 creator A5033746756 @default.
- W72425244 creator A5042612584 @default.
- W72425244 date "2006-03-01" @default.
- W72425244 modified "2023-09-26" @default.
- W72425244 title "Elevated mesenteric vascular pressure does not activate the splenorenal reflex in portal hypertension" @default.
- W72425244 doi "https://doi.org/10.1096/fasebj.20.5.lb36-b" @default.
- W72425244 hasPublicationYear "2006" @default.
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