Matches in SemOpenAlex for { <https://semopenalex.org/work/W72437013> ?p ?o ?g. }
- W72437013 endingPage "183" @default.
- W72437013 startingPage "175" @default.
- W72437013 abstract "Background: Progressive nephropathy represents a substantial source of morbidity and mortality in type 2 diabetes. Increasing albuminuria is a strong predictor of progressive renal dysfunction and heightened cardiovascular risk. Endothelial damage is associated with albuminuria. VonWillebrand factor (vWf) and Thrombomodulin (TM) are possible markers of endothelial dysfunction and damage. Objectives: We studied the relationship between plasma vWf, TM, and urinary albumin excretion. Methods: We conducted on 90 diabetic patients fulfilled the WHO criteria for type 2 diabetes. Diabetic patients were placed into three groups according to urinary albumin concentration (UAC) in a 24-hour urine collection. Group I: included 30 patients with normal urinary albumin concentration (without nephropathy); microalbumin/24 hour urine less than 30 mg. Group II: included 30 patients with microalbuminuria (incipient diabetic nephropathy), microalbumin/24 hour urine from 30 to 299 mg. Group III: included 30 patients with macroalbuminuria (overt diabetic nephropathy); microalbumin/24 hour urine greater than 300 mg. We measured plasma levels of vonWillebrand factor (vWf) and Thrombomodulin (TM) as markers of endothelial dysfunction, to evaluate their relationship to urinary albumin excretion in patients with type 2 diabetes mellitus. Results: There were significant increase in the levels of cholesterol and triglyceride, and significant decrease in HDL in group III compared to the control group, while it was highly significant with group II and III. TM levels showed no significant difference between control group and group I while it was highly significant with group II and III (p Conclusions: These results suggested that generalized vascular endothelial damage occurs in diabetic nephropathy including the microalbuminuric stage. Hence, plasma vWF and TM represents valuable markers of endothelial dysfunction that could be used for early detection of diabetic microvascular complications. Keywords: Endothelial dysfunction, microalbuminuria, thrombomodulin, type 2 diabetes, von-Willebrand factor" @default.
- W72437013 created "2016-06-24" @default.
- W72437013 creator A5021010432 @default.
- W72437013 creator A5045341973 @default.
- W72437013 creator A5060081348 @default.
- W72437013 creator A5063568927 @default.
- W72437013 creator A5068963803 @default.
- W72437013 date "2012-02-04" @default.
- W72437013 modified "2023-09-23" @default.
- W72437013 title "Circulating markers of endothelial dysfunction in type 2 diabetic patients with microalbuminuria" @default.
- W72437013 cites W1519050139 @default.
- W72437013 cites W1578821085 @default.
- W72437013 cites W183746728 @default.
- W72437013 cites W1928894857 @default.
- W72437013 cites W1973386526 @default.
- W72437013 cites W1980067604 @default.
- W72437013 cites W1987902563 @default.
- W72437013 cites W1988802701 @default.
- W72437013 cites W1996230946 @default.
- W72437013 cites W1996506910 @default.
- W72437013 cites W2002603541 @default.
- W72437013 cites W2010339928 @default.
- W72437013 cites W2010818019 @default.
- W72437013 cites W2018036811 @default.
- W72437013 cites W2019730369 @default.
- W72437013 cites W2022475826 @default.
- W72437013 cites W2046809996 @default.
- W72437013 cites W2049734773 @default.
- W72437013 cites W2058271386 @default.
- W72437013 cites W2060516594 @default.
- W72437013 cites W2062793579 @default.
- W72437013 cites W2063122242 @default.
- W72437013 cites W2085957001 @default.
- W72437013 cites W2093221676 @default.
- W72437013 cites W2096177597 @default.
- W72437013 cites W2101085512 @default.
- W72437013 cites W2107432878 @default.
- W72437013 cites W2138674605 @default.
- W72437013 cites W2149820565 @default.
- W72437013 cites W2152420062 @default.
- W72437013 cites W2154774609 @default.
- W72437013 cites W2166523466 @default.
- W72437013 cites W2324841714 @default.
- W72437013 cites W2396694427 @default.
- W72437013 cites W2417827527 @default.
- W72437013 cites W2736029153 @default.
- W72437013 cites W1749892466 @default.
- W72437013 doi "https://doi.org/10.5372/1905-7415.0602.044" @default.
- W72437013 hasPublicationYear "2012" @default.
- W72437013 type Work @default.
- W72437013 sameAs 72437013 @default.
- W72437013 citedByCount "0" @default.
- W72437013 crossrefType "journal-article" @default.
- W72437013 hasAuthorship W72437013A5021010432 @default.
- W72437013 hasAuthorship W72437013A5045341973 @default.
- W72437013 hasAuthorship W72437013A5060081348 @default.
- W72437013 hasAuthorship W72437013A5063568927 @default.
- W72437013 hasAuthorship W72437013A5068963803 @default.
- W72437013 hasConcept C10146269 @default.
- W72437013 hasConcept C126322002 @default.
- W72437013 hasConcept C126894567 @default.
- W72437013 hasConcept C134018914 @default.
- W72437013 hasConcept C201267052 @default.
- W72437013 hasConcept C2776174234 @default.
- W72437013 hasConcept C2777180221 @default.
- W72437013 hasConcept C2777292125 @default.
- W72437013 hasConcept C2779561371 @default.
- W72437013 hasConcept C2779922275 @default.
- W72437013 hasConcept C2780026642 @default.
- W72437013 hasConcept C2780091579 @default.
- W72437013 hasConcept C2780972559 @default.
- W72437013 hasConcept C2781184683 @default.
- W72437013 hasConcept C2781203188 @default.
- W72437013 hasConcept C555293320 @default.
- W72437013 hasConcept C71924100 @default.
- W72437013 hasConcept C77411442 @default.
- W72437013 hasConcept C89560881 @default.
- W72437013 hasConcept C90924648 @default.
- W72437013 hasConceptScore W72437013C10146269 @default.
- W72437013 hasConceptScore W72437013C126322002 @default.
- W72437013 hasConceptScore W72437013C126894567 @default.
- W72437013 hasConceptScore W72437013C134018914 @default.
- W72437013 hasConceptScore W72437013C201267052 @default.
- W72437013 hasConceptScore W72437013C2776174234 @default.
- W72437013 hasConceptScore W72437013C2777180221 @default.
- W72437013 hasConceptScore W72437013C2777292125 @default.
- W72437013 hasConceptScore W72437013C2779561371 @default.
- W72437013 hasConceptScore W72437013C2779922275 @default.
- W72437013 hasConceptScore W72437013C2780026642 @default.
- W72437013 hasConceptScore W72437013C2780091579 @default.
- W72437013 hasConceptScore W72437013C2780972559 @default.
- W72437013 hasConceptScore W72437013C2781184683 @default.
- W72437013 hasConceptScore W72437013C2781203188 @default.
- W72437013 hasConceptScore W72437013C555293320 @default.
- W72437013 hasConceptScore W72437013C71924100 @default.
- W72437013 hasConceptScore W72437013C77411442 @default.
- W72437013 hasConceptScore W72437013C89560881 @default.
- W72437013 hasConceptScore W72437013C90924648 @default.