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- W72437797 abstract "Publisher Summary This chapter discusses the role played by molecular imaging in pulmonary gene therapy, especially positron emission tomography (PET) imaging using [124]I as a radiotracer. Tumor suppressor genes are among the most popular therapeutic targets. Mutated in >50% of lung cancers, p53 is the classic tumor suppressor gene involved in cell-cycle regulation and apoptosis. Gene transfer of p53 in retroviral or adenoviral vectors has confirmed its therapeutic effects in animal models of human lung cancer. Besides p53, mutations in the cyclin-dependent kinase inhibitors, including p16, p21, and p27, are frequently seen in lung carcinoma. The fragile histidine triad (FHIT) gene and melanoma differentiation associated gene (MDA-7) also promote apoptosis while maintaining no toxicity to normal cells. These genes are all promising targets for pulmonary gene therapy. The gene transfer to humans can be achieved using either ex vivo or in vivo strategies. For pulmonary cancer gene therapy, central tumors can often be reached by flexible bronchoscopy and peripheral tumors by established transthoracic radiologic-guided approaches. The vectors used in gene therapy usually contain an expression cassette comprised by the cDNA of interest, and both 5’ upstream and 3’ downstream flanking regions. The 5’ region is the promoter sequence, and the 3’ flanking region usually influences the RNA splicing and polyadenylaiton and post-translational processing. There are a few viral vectors available for gene transfer, including retroviruses, adenoviruses, and adeno-associated viruses. The double-stranded DNA adenovirus is the most widely used vector in pulmonary gene therapy. Adenoviruses have large, complex, linear 36 kb DNA genomes and are known for their high gene transfer efficiency in multiple tissues, especially lung." @default.
- W72437797 created "2016-06-24" @default.
- W72437797 creator A5070049424 @default.
- W72437797 creator A5088055918 @default.
- W72437797 date "2008-01-01" @default.
- W72437797 modified "2023-09-24" @default.
- W72437797 title "Detection of Pulmonary Gene Transfer Using Iodide-124/Positron Emission Tomography" @default.
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- W72437797 doi "https://doi.org/10.1016/b978-012374212-4.50032-8" @default.
- W72437797 hasPublicationYear "2008" @default.
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