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- W72541212 abstract "Abstract The mechanism for inflammation associated tumor development is a central issue for tumor biology and immunology. IL-17 is an important cytokine for inflammatory and autoimmune diseases. Although IL-17 producing cells are detected in cancer patients and tumor bearing mice, the role of IL-17 mediated inflammation in tumor development remains to be determined. In the current studies, we showed that IL-17 receptor-A gene deficient mice (IL-17R-/-) were resistant to chemical induced carcinogenesis in the skin. Moreover, the defect in IL-17R reversed the increased susceptibility of IL-12p35 deficient mice to tumor development. Analysis showed that angiogenesis and infiltration of myeloid cells were inhibited whereas the infiltration of CD8 T cells was increased in the inflamed skin of IL-17R-/- mice. The development of myeloid derived suppressor cells was inhibited in IL-17R-/- mice. Inflammation induced Cox-2 activity and S100A8/A9 proteins were inhibited and inflammation associated epidermal hyperplasia were suppressed in IL-17R-/- mice. Furthermore, the production of tumor promoting inflammatory cytokines IL-1β and TNF-α were reduced. These findings demonstrate that IL-17 signals are required for inflammation associated tumor development. The study provides insights into a novel mechanism by which IL-17 mediates tumor promoting inflammation and induces tumor escape from immune surveillance. It has major implications for targeting IL-17 in prevention and treatment of tumors." @default.
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- W72541212 date "2010-04-01" @default.
- W72541212 modified "2023-10-17" @default.
- W72541212 title "IL-17 promotes inflammation associated tumor development (100.14)" @default.
- W72541212 doi "https://doi.org/10.4049/jimmunol.184.supp.100.14" @default.
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