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- W72611070 abstract "Interferon exerts its action on cells by inducing several enzymes. One of the enzymes induced is the (2′-5′) oligo-isoadenylate synthetase which, in the presence of double-stranded (ds) RNA polymerizes ATP into ppp(A2′p) n 5′A oligonucleotides. One of the functions of these oligonucleotides is to activate an endonuclease, RNase F, which leads to inhibition of protein synthesis. In cell free systems, mRNA is degraded by RNase F. In SV40-infected monkey cells, in which interferon produces a selective inhibition of viral mRNA translation, mRNAs are not degraded but cleavage of ribosomal RNA is observed." @default.
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- W72611070 date "1979-01-01" @default.
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- W72611070 title "STUDIES ON INTERFERON ACTION: SYNTHESIS, DEGRADATION AND BIOLOGICAL ACTIVITY OF (2′-5′) OLIGO-ISOADENYLATE" @default.
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- W72611070 doi "https://doi.org/10.1016/b978-0-12-417580-8.50035-6" @default.
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