Matches in SemOpenAlex for { <https://semopenalex.org/work/W72622044> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W72622044 abstract "Sodium nitroprusside (SNP) is a powerful vasodilatatory agent, which similar to GTN releases nitric oxide (NO) but in contrast does not to pass blood-brain barrier. Nevertheless it has already been used in animal models without any knowledge of its headache inducing potential. We hypothesized that SNP would induce headache and vasodilation of cephalic and radial but not cerebral arteries. Five healthy volunteers received intravenous infusion of SNP in a non-randomized dose-titration (1-5 µg/kg/min) study. We recorded headache intensity (verbal rating scale from 0–10), velocity in the middle cerebral artery (VMCA), and diameters of the superficial temporal artery (STA) and radial artery (RA). All participants reported a dose related headache (median peak = 2.5, range 0-3). SNP dilated the STA and RA, caused a marked increase of heart rate and a decrease of mean arterial pressure (MAP) and PetCO2. We found that SNP decreased the velocity of the MCA, but this was cancelled by a decrease of CBF due to hypocapnia. In conclusion, the present study shows that SNP is a headache inducing agent with close similarities to headaches induced by GTN and possibly without effect on intracerebral arteries." @default.
- W72622044 created "2016-06-24" @default.
- W72622044 creator A5023775224 @default.
- W72622044 creator A5036844498 @default.
- W72622044 creator A5054623919 @default.
- W72622044 creator A5067992347 @default.
- W72622044 date "2013-02-01" @default.
- W72622044 modified "2023-09-27" @default.
- W72622044 title "The effect of sodium nitroprusside on cerebral haemodynamic and headache in healthy subjects" @default.
- W72622044 doi "https://doi.org/10.1186/1129-2377-14-s1-p232" @default.
- W72622044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3620086" @default.
- W72622044 hasPublicationYear "2013" @default.
- W72622044 type Work @default.
- W72622044 sameAs 72622044 @default.
- W72622044 citedByCount "1" @default.
- W72622044 countsByYear W726220442018 @default.
- W72622044 crossrefType "journal-article" @default.
- W72622044 hasAuthorship W72622044A5023775224 @default.
- W72622044 hasAuthorship W72622044A5036844498 @default.
- W72622044 hasAuthorship W72622044A5054623919 @default.
- W72622044 hasAuthorship W72622044A5067992347 @default.
- W72622044 hasBestOaLocation W726220441 @default.
- W72622044 hasConcept C118552586 @default.
- W72622044 hasConcept C126322002 @default.
- W72622044 hasConcept C164705383 @default.
- W72622044 hasConcept C16568411 @default.
- W72622044 hasConcept C178853913 @default.
- W72622044 hasConcept C2779526319 @default.
- W72622044 hasConcept C2779610285 @default.
- W72622044 hasConcept C2991975920 @default.
- W72622044 hasConcept C42219234 @default.
- W72622044 hasConcept C519581460 @default.
- W72622044 hasConcept C71924100 @default.
- W72622044 hasConceptScore W72622044C118552586 @default.
- W72622044 hasConceptScore W72622044C126322002 @default.
- W72622044 hasConceptScore W72622044C164705383 @default.
- W72622044 hasConceptScore W72622044C16568411 @default.
- W72622044 hasConceptScore W72622044C178853913 @default.
- W72622044 hasConceptScore W72622044C2779526319 @default.
- W72622044 hasConceptScore W72622044C2779610285 @default.
- W72622044 hasConceptScore W72622044C2991975920 @default.
- W72622044 hasConceptScore W72622044C42219234 @default.
- W72622044 hasConceptScore W72622044C519581460 @default.
- W72622044 hasConceptScore W72622044C71924100 @default.
- W72622044 hasIssue "S1" @default.
- W72622044 hasLocation W726220441 @default.
- W72622044 hasLocation W726220442 @default.
- W72622044 hasOpenAccess W72622044 @default.
- W72622044 hasPrimaryLocation W726220441 @default.
- W72622044 hasRelatedWork W1994518150 @default.
- W72622044 hasRelatedWork W2010159749 @default.
- W72622044 hasRelatedWork W2081120659 @default.
- W72622044 hasRelatedWork W2087739923 @default.
- W72622044 hasRelatedWork W2137647015 @default.
- W72622044 hasRelatedWork W2885607896 @default.
- W72622044 hasRelatedWork W4235128451 @default.
- W72622044 hasRelatedWork W4241555251 @default.
- W72622044 hasRelatedWork W4250233948 @default.
- W72622044 hasRelatedWork W1709854730 @default.
- W72622044 hasVolume "14" @default.
- W72622044 isParatext "false" @default.
- W72622044 isRetracted "false" @default.
- W72622044 magId "72622044" @default.
- W72622044 workType "article" @default.