FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W72644610> ?p ?o ?g. }

• W72644610 endingPage "796" @default.
• W72644610 startingPage "789" @default.
• W72644610 abstract "To characterize the cell(s) responsible for the suppressor-cell dysfunction in active systemic lupus erythematosus (SLE), we fractionated blood mononuclear cells into thymus-derived (T), bone marrow-derived (B), and monocyte-depleted populations. Various cell populations from active SLE, inactive SLE, or normals, were activated with Concanavalin A, washed, and then co-cultured with active SLE cells. Soluble immune response suppressor (SIRS) from culture supernates of the activated cells was also used for the possible correction of the suppressor-cell dysfunction. Suppression was tested by enumerating DNA-binding cells by radioautography and by quantitating anti-DNA antibody in culture supernates by radioimmunoassay; and immunoglobulin was tested in cells and supernates by the immunofluorescence and the immunofluor techniques, respectively. Except for the numbers of DNA-binding cells, which were not suppressed, all the other three parameters in co-cultures with cells from active SLE patients were suppressed by Concanavalin A-activated cells (P < 0.001), or by SIRS (P < 0.05) from normals or inactive SLE patients. Concanavalin A-activated autologous or allogeneic active SLE cells and nonactivated cells from active or inactive SLE failed to suppress the various B-cell functions. Nonactivated normal cells suppressed levels of anti-DNA and immunoglobulin in supernates (P < 0.05). In characterizing the cells responsible for the suppressor dysfunction, it was clear from the results that T cells responsive to Concanavalin A activation are deficient in active SLE and fail to generate SIRS. On the other hand, monocytes from active SLE patients are responsive to signals from the activated T cells of normals or inactive SLE donors. Because SIRS suppresses active SLE cells in vitro, it might be considered therapeutically for the in vivo modulation of SLE." @default.
• W72644610 created "2016-06-24" @default.
• W72644610 creator A5036815432 @default.
• W72644610 creator A5051037095 @default.
• W72644610 date "1978-10-01" @default.
• W72644610 modified "2023-10-16" @default.
• W72644610 title "Suppressor-Cell Dysfunction in Systemic Lupus Erythematosus" @default.
• W72644610 cites W122388576 @default.
• W72644610 cites W1497436334 @default.
• W72644610 cites W1967270857 @default.
• W72644610 cites W1974148619 @default.
• W72644610 cites W1985895204 @default.
• W72644610 cites W1986720974 @default.
• W72644610 cites W1999770566 @default.
• W72644610 cites W2001349905 @default.
• W72644610 cites W2006378614 @default.
• W72644610 cites W2008575549 @default.
• W72644610 cites W2013304622 @default.
• W72644610 cites W2015479119 @default.
• W72644610 cites W2033478241 @default.
• W72644610 cites W2041370911 @default.
• W72644610 cites W2048545837 @default.
• W72644610 cites W2049037114 @default.
• W72644610 cites W2072149754 @default.
• W72644610 cites W2081295928 @default.
• W72644610 cites W2081817833 @default.
• W72644610 cites W2089892749 @default.
• W72644610 cites W2133254688 @default.
• W72644610 cites W2134533879 @default.
• W72644610 cites W2139330264 @default.
• W72644610 cites W2146741157 @default.
• W72644610 cites W2319676754 @default.
• W72644610 cites W2404522484 @default.
• W72644610 cites W2414147248 @default.
• W72644610 doi "https://doi.org/10.1172/jci109190" @default.
• W72644610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/371830" @default.
• W72644610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/308952" @default.
• W72644610 hasPublicationYear "1978" @default.
• W72644610 type Work @default.
• W72644610 sameAs 72644610 @default.
• W72644610 citedByCount "160" @default.
• W72644610 countsByYear W726446102022 @default.
• W72644610 countsByYear W726446102023 @default.
• W72644610 crossrefType "journal-article" @default.
• W72644610 hasAuthorship W72644610A5036815432 @default.
• W72644610 hasAuthorship W72644610A5051037095 @default.
• W72644610 hasBestOaLocation W726446101 @default.
• W72644610 hasConcept C104317684 @default.
• W72644610 hasConcept C137061746 @default.
• W72644610 hasConcept C153911025 @default.
• W72644610 hasConcept C159654299 @default.
• W72644610 hasConcept C179185449 @default.
• W72644610 hasConcept C185592680 @default.
• W72644610 hasConcept C19869320 @default.
• W72644610 hasConcept C202751555 @default.
• W72644610 hasConcept C203014093 @default.
• W72644610 hasConcept C2775915377 @default.
• W72644610 hasConcept C2781184567 @default.
• W72644610 hasConcept C54355233 @default.
• W72644610 hasConcept C552990157 @default.
• W72644610 hasConcept C55493867 @default.
• W72644610 hasConcept C64241487 @default.
• W72644610 hasConcept C81885089 @default.
• W72644610 hasConcept C86803240 @default.
• W72644610 hasConcept C8891405 @default.
• W72644610 hasConceptScore W72644610C104317684 @default.
• W72644610 hasConceptScore W72644610C137061746 @default.
• W72644610 hasConceptScore W72644610C153911025 @default.
• W72644610 hasConceptScore W72644610C159654299 @default.
• W72644610 hasConceptScore W72644610C179185449 @default.
• W72644610 hasConceptScore W72644610C185592680 @default.
• W72644610 hasConceptScore W72644610C19869320 @default.
• W72644610 hasConceptScore W72644610C202751555 @default.
• W72644610 hasConceptScore W72644610C203014093 @default.
• W72644610 hasConceptScore W72644610C2775915377 @default.
• W72644610 hasConceptScore W72644610C2781184567 @default.
• W72644610 hasConceptScore W72644610C54355233 @default.
• W72644610 hasConceptScore W72644610C552990157 @default.
• W72644610 hasConceptScore W72644610C55493867 @default.
• W72644610 hasConceptScore W72644610C64241487 @default.
• W72644610 hasConceptScore W72644610C81885089 @default.
• W72644610 hasConceptScore W72644610C86803240 @default.
• W72644610 hasConceptScore W72644610C8891405 @default.
• W72644610 hasIssue "4" @default.
• W72644610 hasLocation W726446101 @default.
• W72644610 hasLocation W726446102 @default.
• W72644610 hasLocation W726446103 @default.
• W72644610 hasLocation W726446104 @default.
• W72644610 hasOpenAccess W72644610 @default.
• W72644610 hasPrimaryLocation W726446101 @default.
• W72644610 hasRelatedWork W1555319444 @default.
• W72644610 hasRelatedWork W1966874777 @default.
• W72644610 hasRelatedWork W1971654990 @default.
• W72644610 hasRelatedWork W2018789637 @default.
• W72644610 hasRelatedWork W2021889556 @default.
• W72644610 hasRelatedWork W2028085065 @default.
• W72644610 hasRelatedWork W2050802214 @default.
• W72644610 hasRelatedWork W2072209936 @default.

• next