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- W72670545 abstract "Allapinine (lappaconitine hydrobromide) – for the treatment of cardiac arrhythmias. Allapinine, like other antiarrhythmics class 1C, long blocks «fast» Na+-channels in the open state. However, some features of the electrophysiological effects of allapinine distinguish it from the currently used antiarrhythmics class 1C and determine qualitatively different from that of these drugs, the mechanisms of antiarrhythmic action. Drug target genes identified in modeling akonitine arrhythmias in rats. Found that allapinine causes changes mRNA levels of genes coding for different types of K+-channels ( Kcna6, Kcnj1, Kcnj4, Kcnq2, Kcnq4 ), Ca2+-channel ( Cacna1g ), vesicular transporter of acetylcholine ( Slc18a3 ), genes encoding the Na+-channel ( Scn8a ), K+-channels ( Kcne1, Kcns1 ), membrane transporters ( Atp4a, Slc6a9 ). Our data suggest that the effect on the expression of target genes of ion channels rat cardiomyocytes allapinine has both similar and different properties of the principal representatives of class 1C antiarrhythmic drugs." @default.
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- W72670545 date "2012-01-01" @default.
- W72670545 modified "2023-09-26" @default.
- W72670545 title "Влияние аллапинина на экспрессию генов ионных каналов кардиомиоцитов" @default.
- W72670545 hasPublicationYear "2012" @default.
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