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- W7267333 abstract "Publisher Summary This chapter discusses the successful utilization of gene transfection and characterization of one of the stably transformed cell lines, C86. The expression of the CaM gene was studied in mouse C127 clones containing extra copies of the chicken CaM gene. The constructed vector utilized for studies included the complete structural portion of the chicken CaM gene ligated to the metallothionein promotor. This hybrid gene was cloned in a vector containing the genome of the Bovine Papilloma Virus (BPV) and transfected in to mouse C127 cells. Northern blot analysis was performed on total RNA extracted from exponentially growing C127, 6.8 and C86 cells. Clone C86 has been extremely valuable in uncovering the levels of regulation for CaM. It is apparent that total levels of CaM by themselves are insufficient to trigger a more rapid cell cycle because although clone C86 has an increase in CaM, the doubling time is not shortened. The fact that the doubling time of C86 is lengthened would still suggest that CaM plays a role in cell proliferation but that this regulation is more complex than a simple concentration effect and most likely other factors such as calmodulin binding proteins must be involved." @default.
- W7267333 created "2016-06-24" @default.
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- W7267333 date "1987-01-01" @default.
- W7267333 modified "2023-10-16" @default.
- W7267333 title "LEVELS OF CALMODULIN ARE STRICTLY REGULATED IN CELLS TRANSFECTED WITH AN EXOGENOUS CaM GENE: EFFECTS ON ENDOGENOUS CaM REGULATION AND CELL CYCLE PROGRESSION11Supported by a Development Grant No DG-319 from the Medical Reasearch Council (MRC) of Canada." @default.
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- W7267333 doi "https://doi.org/10.1016/b978-0-12-521040-9.50054-1" @default.
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