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- W72673678 abstract "Publisher Summary This chapter provides an overview of the kallikrein (KLK)–kinin system. The chapter highlights the discovery of the physiological and pathological roles of kinins, showing their involvement in vasodilation, regulation of blood pressure, inflammation, and the production of pain. Thus, through the knowledge gained from these pioneering basic studies, the actions of kinins are unveiled, leading to the understanding of many diseases associated with kinin formation. The existence of the KLK–kinin system was first disclosed nearly 50 years ago when a series of coincidental discoveries by two independent groups came together revealing the major biological roles of the system. Werle found that KLK preparations from human urine elicited contractions in isolated dog intestine. Thus, KLK had been shown to possess two activities: induction of hypotension in vivo and contraction of isolated intestinal smooth muscle." @default.
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- W72673678 date "1997-01-01" @default.
- W72673678 modified "2023-09-23" @default.
- W72673678 title "Discovery of Bradykinin and the Kallikrein—Kinin System" @default.
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- W72673678 doi "https://doi.org/10.1016/b978-012249340-9/50003-6" @default.
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