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- W72686852 endingPage "85" @default.
- W72686852 startingPage "25" @default.
- W72686852 abstract "Adrenergic receptors are critical mediators of sympaiMolecular Cardiology Program, Vihysiological responses. Activated by the neurotransmitter and neurohormone, norepinephrine and epinephrine, released from sympathetic nerve endings and the adrenal medulla, respectively, they play a central role in this evolutionarily ancient defense system that regulates many physiological functions, including those involved in circulatory, metabolic, respiratory, and central nervous system homeostasis. In addition, alterations in the regulation and molecular structure of adrenergic receptors have been implicated in a variety of diseases, and drugs targeting these receptors are important and widely used therapeutics. The molecular cloning of the first adrenergic receptor in 1986 revealed structural homology with the functionally related rhodopsin visual transduction system—a finding that led to the realization that these receptors formed a new superfamily of proteins, now known as G protein-coupled receptors. Since that time, a plethora of structure-function studies have provided major insights into the molecular determinants of adrenergic receptor ligand-binding, activation, and signaling, many of which are relevant not only to the adrenergic receptor family but also, more generally, to the broader superfamily of G protein-coupled receptors. These advances in our understanding of adrenergic receptor activation, regulation, and functioning are reviewed in this chapter." @default.
- W72686852 created "2016-06-24" @default.
- W72686852 creator A5008085346 @default.
- W72686852 creator A5021863838 @default.
- W72686852 creator A5032822616 @default.
- W72686852 date "2006-01-01" @default.
- W72686852 modified "2023-10-18" @default.
- W72686852 title "Ligand Binding, Activation, and Agonist Trafficking" @default.
- W72686852 cites W1482605042 @default.
- W72686852 cites W1483932465 @default.
- W72686852 cites W1489775551 @default.
- W72686852 cites W1493609355 @default.
- W72686852 cites W1493688737 @default.
- W72686852 cites W1499502752 @default.
- W72686852 cites W1502005164 @default.
- W72686852 cites W1503798695 @default.
- W72686852 cites W1504083190 @default.
- W72686852 cites W1506108353 @default.
- W72686852 cites W1508005550 @default.
- W72686852 cites W1509677149 @default.
- W72686852 cites W1511344849 @default.
- W72686852 cites W1511840890 @default.
- W72686852 cites W1517863661 @default.
- W72686852 cites W1521595809 @default.
- W72686852 cites W1526269615 @default.
- W72686852 cites W1540109635 @default.
- W72686852 cites W1554771869 @default.
- W72686852 cites W1567780540 @default.
- W72686852 cites W1569529718 @default.
- W72686852 cites W1573258040 @default.
- W72686852 cites W1581548318 @default.
- W72686852 cites W1582593880 @default.
- W72686852 cites W1582749741 @default.
- W72686852 cites W1584684122 @default.
- W72686852 cites W1588835435 @default.
- W72686852 cites W1590966229 @default.
- W72686852 cites W1602157168 @default.
- W72686852 cites W1604013791 @default.
- W72686852 cites W1604652736 @default.
- W72686852 cites W1605053704 @default.
- W72686852 cites W1633206839 @default.
- W72686852 cites W1654237604 @default.
- W72686852 cites W166360991 @default.
- W72686852 cites W1729873003 @default.
- W72686852 cites W1769585641 @default.
- W72686852 cites W1779435222 @default.
- W72686852 cites W1833104430 @default.
- W72686852 cites W1855952875 @default.
- W72686852 cites W1878502177 @default.
- W72686852 cites W1916260872 @default.
- W72686852 cites W1919770365 @default.
- W72686852 cites W1925288771 @default.
- W72686852 cites W1938890915 @default.
- W72686852 cites W1945187946 @default.
- W72686852 cites W1954206909 @default.
- W72686852 cites W1958218436 @default.
- W72686852 cites W1958742527 @default.
- W72686852 cites W1963616721 @default.
- W72686852 cites W1963763914 @default.
- W72686852 cites W1964626085 @default.
- W72686852 cites W1966101832 @default.
- W72686852 cites W1967145591 @default.
- W72686852 cites W1967554858 @default.
- W72686852 cites W1969331222 @default.
- W72686852 cites W1969344942 @default.
- W72686852 cites W1969409769 @default.
- W72686852 cites W1970435627 @default.
- W72686852 cites W1970736649 @default.
- W72686852 cites W1971390138 @default.
- W72686852 cites W1971824802 @default.
- W72686852 cites W1972870617 @default.
- W72686852 cites W1973001614 @default.
- W72686852 cites W1973111841 @default.
- W72686852 cites W1973197643 @default.
- W72686852 cites W1974387855 @default.
- W72686852 cites W1974737364 @default.
- W72686852 cites W1976952504 @default.
- W72686852 cites W1979591208 @default.
- W72686852 cites W1980445909 @default.
- W72686852 cites W1983069070 @default.
- W72686852 cites W1985407755 @default.
- W72686852 cites W1985525186 @default.
- W72686852 cites W1986558398 @default.
- W72686852 cites W1987521059 @default.
- W72686852 cites W1988274287 @default.
- W72686852 cites W1988328173 @default.
- W72686852 cites W1989596657 @default.
- W72686852 cites W1989778950 @default.
- W72686852 cites W1990183064 @default.
- W72686852 cites W1990282476 @default.
- W72686852 cites W1991002818 @default.
- W72686852 cites W1992787746 @default.
- W72686852 cites W1994019984 @default.
- W72686852 cites W1994821631 @default.
- W72686852 cites W1994910406 @default.
- W72686852 cites W1996260808 @default.
- W72686852 cites W1998565035 @default.
- W72686852 cites W1999453187 @default.