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• W72689258 startingPage "29" @default.
• W72689258 abstract "Conclusions and future perspectivesThe more we study the NPY family of receptors, the more functions are assigned to them. Developments of knockout animals and receptor selective antagonists have revealed several novel functions of the NPY-family receptors. However, the complete picture of what receptor is responsible for a particular function is still illusive, perhaps due to the large degree of redundancy in the NPY peptides and receptors. Double or conditional knockout animals will no doubt become valuable tools here [211, 212]. In addition, developmental compensation to the loss of NPY or Y receptors is poorly understood and this may account for some of the phenotypes or lack thereof observed in behavioral studies.Successful attempts to develop clinically useful Y1 or Y5 selective antagonists have failed due to lack of efficacy in preclinical models of food intake. The vast coexpression of the Y1 and Y5 receptors in the brain along with the evidence for a Y1/Y5 hetrodimer suggests that the alleged “feeding receptor” responsible for the centrally regulated orexigenic effects of NPY and PYY may be via a heterodimer. However, the recently re-discovered anorectic effects of peripheral agonism at the Y2 and Y4 receptors may, in fact, constitute more appealing treatment strategies for obesity and the metabolic syndrome. Other interesting areas where drugs acting at NPY receptor have prospects as novel therapeutics include alcoholism and various mood disorders. Finally, several findings suggest that the NPY family peptides and receptors are involved in nociception and inflammation, aspects that have been somewhat neglected compared to the predominant interest in the metabolic functions of this fascinating peptide family." @default.
• W72689258 created "2016-06-24" @default.
• W72689258 creator A5012426969 @default.
• W72689258 creator A5050644618 @default.
• W72689258 creator A5053874640 @default.
• W72689258 date "2005-12-22" @default.
• W72689258 modified "2023-09-23" @default.
• W72689258 title "Function, distribution and molecular pharmacology of NPY-family receptors" @default.
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