Matches in SemOpenAlex for { <https://semopenalex.org/work/W7268927> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W7268927 endingPage "30" @default.
- W7268927 startingPage "21" @default.
- W7268927 abstract "Cisplatin (Platinol) has an important dose-response relationship in ovarian cancer. We have used high-dose cisplatin (40 mg/m2q d X 5) administered in 250 mL 3% saline and 6 L/d of saline hydration in a phase II trial in refractory ovarian cancer patients and together with cyclophosphamide (Cytoxan) (200 mg/m2 qd X 5) in previously untreated advanced ovarian cancer patients. High-dose cisplatin produced a 32% response rate in the phase II trial with a median survival of 12 months for all patients entered in the study and 16 months for responding patients. In previously untreated patients, the preliminary results indicate that intensive treatment with high-dose cisplatin and cyclophosphamide of short duration (3 to 4 months) can produce a high complete remission rate (60%). The dose-limiting toxicity of high-dose cisplatin has been peripheral neuropathy, which limits the number of cycles of high-dose cisplatin that can be administered. Alternative ways to administer higher doses of cisplatin include the use of sodium thiosulfate as a protective agent and the intraperitoneal administration of cisplatin in ovarian cancer patients. These results demonstrate that the cisplatin dose is an important factor in achieving improved results in the treatment of ovarian cancer." @default.
- W7268927 created "2016-06-24" @default.
- W7268927 creator A5075213038 @default.
- W7268927 creator A5086638104 @default.
- W7268927 date "1985-12-01" @default.
- W7268927 modified "2023-09-23" @default.
- W7268927 title "High-dose cisplatin therapy in ovarian cancer." @default.
- W7268927 cites W128774778 @default.
- W7268927 cites W1484639328 @default.
- W7268927 cites W1692908748 @default.
- W7268927 cites W1959295051 @default.
- W7268927 cites W1993938769 @default.
- W7268927 cites W1998423615 @default.
- W7268927 cites W2010954378 @default.
- W7268927 cites W2023160068 @default.
- W7268927 cites W2023496931 @default.
- W7268927 cites W2028940434 @default.
- W7268927 cites W2032528970 @default.
- W7268927 cites W2046968173 @default.
- W7268927 cites W2049402875 @default.
- W7268927 cites W2049565457 @default.
- W7268927 cites W2052055451 @default.
- W7268927 cites W2148441277 @default.
- W7268927 cites W2179956917 @default.
- W7268927 cites W2258220157 @default.
- W7268927 cites W2260271187 @default.
- W7268927 cites W2409767001 @default.
- W7268927 cites W2419435391 @default.
- W7268927 cites W2467703080 @default.
- W7268927 cites W45574792 @default.
- W7268927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3909419" @default.
- W7268927 hasPublicationYear "1985" @default.
- W7268927 type Work @default.
- W7268927 sameAs 7268927 @default.
- W7268927 citedByCount "31" @default.
- W7268927 countsByYear W72689272012 @default.
- W7268927 countsByYear W72689272015 @default.
- W7268927 countsByYear W72689272017 @default.
- W7268927 countsByYear W72689272019 @default.
- W7268927 crossrefType "journal-article" @default.
- W7268927 hasAuthorship W7268927A5075213038 @default.
- W7268927 hasAuthorship W7268927A5086638104 @default.
- W7268927 hasConcept C121608353 @default.
- W7268927 hasConcept C126322002 @default.
- W7268927 hasConcept C126894567 @default.
- W7268927 hasConcept C143998085 @default.
- W7268927 hasConcept C151032500 @default.
- W7268927 hasConcept C179104552 @default.
- W7268927 hasConcept C185592680 @default.
- W7268927 hasConcept C2776694085 @default.
- W7268927 hasConcept C2776755627 @default.
- W7268927 hasConcept C2777397205 @default.
- W7268927 hasConcept C2778239845 @default.
- W7268927 hasConcept C2779525547 @default.
- W7268927 hasConcept C2780427987 @default.
- W7268927 hasConcept C29730261 @default.
- W7268927 hasConcept C71924100 @default.
- W7268927 hasConcept C90924648 @default.
- W7268927 hasConceptScore W7268927C121608353 @default.
- W7268927 hasConceptScore W7268927C126322002 @default.
- W7268927 hasConceptScore W7268927C126894567 @default.
- W7268927 hasConceptScore W7268927C143998085 @default.
- W7268927 hasConceptScore W7268927C151032500 @default.
- W7268927 hasConceptScore W7268927C179104552 @default.
- W7268927 hasConceptScore W7268927C185592680 @default.
- W7268927 hasConceptScore W7268927C2776694085 @default.
- W7268927 hasConceptScore W7268927C2776755627 @default.
- W7268927 hasConceptScore W7268927C2777397205 @default.
- W7268927 hasConceptScore W7268927C2778239845 @default.
- W7268927 hasConceptScore W7268927C2779525547 @default.
- W7268927 hasConceptScore W7268927C2780427987 @default.
- W7268927 hasConceptScore W7268927C29730261 @default.
- W7268927 hasConceptScore W7268927C71924100 @default.
- W7268927 hasConceptScore W7268927C90924648 @default.
- W7268927 hasIssue "4 Suppl 6" @default.
- W7268927 hasLocation W72689271 @default.
- W7268927 hasOpenAccess W7268927 @default.
- W7268927 hasPrimaryLocation W72689271 @default.
- W7268927 hasRelatedWork W2062239485 @default.
- W7268927 hasRelatedWork W2076599170 @default.
- W7268927 hasRelatedWork W2079913422 @default.
- W7268927 hasRelatedWork W2090850966 @default.
- W7268927 hasRelatedWork W2281462989 @default.
- W7268927 hasRelatedWork W2415978481 @default.
- W7268927 hasRelatedWork W2439248396 @default.
- W7268927 hasRelatedWork W2530877275 @default.
- W7268927 hasRelatedWork W363598932 @default.
- W7268927 hasRelatedWork W7268927 @default.
- W7268927 hasVolume "12" @default.
- W7268927 isParatext "false" @default.
- W7268927 isRetracted "false" @default.
- W7268927 magId "7268927" @default.
- W7268927 workType "article" @default.