FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W72735737> ?p ?o ?g. }

• W72735737 endingPage "50" @default.
• W72735737 startingPage "2736" @default.
• W72735737 abstract "The present work critically reviews the evidence for an involvement of free radicals in the pathophysiology of acute pancreatitis and the potential of treatment with antioxidants and scavenger substances. Data originating from clinical trials, experimental pancreatitis studies and in vitro investigations are included. Enhanced free radical activities and increased concentrations of lipid peroxides in plasma and tissue have been found in both patients and experimental animals with acute pancreatitis. The individual contribution of possible sources of free radicals (e.g., invading inflammatory cells, xanthine oxidase, cytochromes P450, nitric oxide synthase) is not yet clear, however. Since prophylactic administration of antioxidants diminished, in particular, pancreatic edema formation, free radicals seem to play an important role in the genesis of edema in acute pancreatitis. An involvement of free radicals in the pathogenesis of pancreatic necrosis could not yet be proven. Thus, no antioxidant treatment has proven useful for therapy of fulminant pancreatitis in animals to date. However, in severe acute pancreatitis characterized by death occurring after 12-18 hours, the seleno-organic compound Ebselen, which has a glutathione peroxidase-like activity, and the membrane permeable ascorbic acid derivative CV-3611 have been demonstrated to be effective. To date, controlled clinical studies have failed to demonstrate the therapeutic efficacy of antioxidant selenium or glutathione precursor supplementation. Therefore, further controlled clinical trials are needed to determine whether supplements of antioxidants can alter the clinical course of acute pancreatitis. Since the nitric oxide radical may even protect the pancreas, a purely negative discussion of the role of free radicals on the pancreas is not justified. The actual role of free radicals in acute pancreatitis, i.e. serving the body's defense against infection, being an epiphenomenon of the inflammatory process without pathophysiological relevance, or having true pathogenic significance, is not yet clear. Lipid peroxidation may perhaps not be the cause but rather the sequel of pancreatic inflammation and may likely reflect the severity of the systemic inflammatory response rather than that of pancreatic parenchyma damage. In vitro, exposure of isolated pancreatic acinar cells to oxidative stress caused rapid cell damage and death. Such knowledge from cellular studies might help to plan therapeutical trials to evaluate potentially effective therapies in the experimental animal, as well as in patients suffering from pancreatitis. Thus, to further clarify the role of oxidative stress in acute pancreatitis, an integrated approach is needed, including investigations at various biological levels, from isolated cells or even organelles to laboratory animals and, finally, clinical studies in man." @default.
• W72735737 created "2016-06-24" @default.
• W72735737 creator A5031436649 @default.
• W72735737 creator A5040504077 @default.
• W72735737 creator A5048066472 @default.
• W72735737 creator A5077164009 @default.
• W72735737 creator A5078344125 @default.
• W72735737 creator A5082437668 @default.
• W72735737 date "1999-11-27" @default.
• W72735737 modified "2023-09-23" @default.
• W72735737 title "Oxidative stress in acute pancreatitis." @default.
• W72735737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10576339" @default.
• W72735737 hasPublicationYear "1999" @default.
• W72735737 type Work @default.
• W72735737 sameAs 72735737 @default.
• W72735737 citedByCount "56" @default.
• W72735737 countsByYear W727357372012 @default.
• W72735737 countsByYear W727357372013 @default.
• W72735737 countsByYear W727357372015 @default.
• W72735737 countsByYear W727357372016 @default.
• W72735737 countsByYear W727357372017 @default.
• W72735737 countsByYear W727357372020 @default.
• W72735737 countsByYear W727357372022 @default.
• W72735737 crossrefType "journal-article" @default.
• W72735737 hasAuthorship W72735737A5031436649 @default.
• W72735737 hasAuthorship W72735737A5040504077 @default.
• W72735737 hasAuthorship W72735737A5048066472 @default.
• W72735737 hasAuthorship W72735737A5077164009 @default.
• W72735737 hasAuthorship W72735737A5078344125 @default.
• W72735737 hasAuthorship W72735737A5082437668 @default.
• W72735737 hasConcept C126322002 @default.
• W72735737 hasConcept C181199279 @default.
• W72735737 hasConcept C185592680 @default.
• W72735737 hasConcept C2775838275 @default.
• W72735737 hasConcept C2775967933 @default.
• W72735737 hasConcept C2776151105 @default.
• W72735737 hasConcept C2776670229 @default.
• W72735737 hasConcept C2778004101 @default.
• W72735737 hasConcept C2778102346 @default.
• W72735737 hasConcept C2778760513 @default.
• W72735737 hasConcept C2779138974 @default.
• W72735737 hasConcept C2986274086 @default.
• W72735737 hasConcept C31903555 @default.
• W72735737 hasConcept C519581460 @default.
• W72735737 hasConcept C538909803 @default.
• W72735737 hasConcept C55493867 @default.
• W72735737 hasConcept C71924100 @default.
• W72735737 hasConcept C98274493 @default.
• W72735737 hasConceptScore W72735737C126322002 @default.
• W72735737 hasConceptScore W72735737C181199279 @default.
• W72735737 hasConceptScore W72735737C185592680 @default.
• W72735737 hasConceptScore W72735737C2775838275 @default.
• W72735737 hasConceptScore W72735737C2775967933 @default.
• W72735737 hasConceptScore W72735737C2776151105 @default.
• W72735737 hasConceptScore W72735737C2776670229 @default.
• W72735737 hasConceptScore W72735737C2778004101 @default.
• W72735737 hasConceptScore W72735737C2778102346 @default.
• W72735737 hasConceptScore W72735737C2778760513 @default.
• W72735737 hasConceptScore W72735737C2779138974 @default.
• W72735737 hasConceptScore W72735737C2986274086 @default.
• W72735737 hasConceptScore W72735737C31903555 @default.
• W72735737 hasConceptScore W72735737C519581460 @default.
• W72735737 hasConceptScore W72735737C538909803 @default.
• W72735737 hasConceptScore W72735737C55493867 @default.
• W72735737 hasConceptScore W72735737C71924100 @default.
• W72735737 hasConceptScore W72735737C98274493 @default.
• W72735737 hasIssue "29" @default.
• W72735737 hasLocation W727357371 @default.
• W72735737 hasOpenAccess W72735737 @default.
• W72735737 hasPrimaryLocation W727357371 @default.
• W72735737 hasRelatedWork W2003594453 @default.
• W72735737 hasRelatedWork W2016879447 @default.
• W72735737 hasRelatedWork W2017716438 @default.
• W72735737 hasRelatedWork W2055163424 @default.
• W72735737 hasRelatedWork W2064964369 @default.
• W72735737 hasRelatedWork W2150441042 @default.
• W72735737 hasRelatedWork W2706317929 @default.
• W72735737 hasRelatedWork W2946066530 @default.
• W72735737 hasRelatedWork W2984807564 @default.
• W72735737 hasRelatedWork W2189500330 @default.
• W72735737 hasVolume "46" @default.
• W72735737 isParatext "false" @default.
• W72735737 isRetracted "false" @default.
• W72735737 magId "72735737" @default.
• W72735737 workType "article" @default.