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• W72800539 abstract "Research Article1 June 1990free access Transcriptional and post-transcriptional regulation of TcR, CD4 and CD8 gene expression during activation of normal human T lymphocytes. F. Paillard F. Paillard Laboratoire d'Immunologie et Oncologie des Maladies Rétrovirales, INSERM U 152, CNRS URA 628, Hôpital Cochin, Paris, France. Search for more papers by this author G. Sterkers G. Sterkers Laboratoire d'Immunologie et Oncologie des Maladies Rétrovirales, INSERM U 152, CNRS URA 628, Hôpital Cochin, Paris, France. Search for more papers by this author C. Vaquero C. Vaquero Laboratoire d'Immunologie et Oncologie des Maladies Rétrovirales, INSERM U 152, CNRS URA 628, Hôpital Cochin, Paris, France. Search for more papers by this author F. Paillard F. Paillard Laboratoire d'Immunologie et Oncologie des Maladies Rétrovirales, INSERM U 152, CNRS URA 628, Hôpital Cochin, Paris, France. Search for more papers by this author G. Sterkers G. Sterkers Laboratoire d'Immunologie et Oncologie des Maladies Rétrovirales, INSERM U 152, CNRS URA 628, Hôpital Cochin, Paris, France. Search for more papers by this author C. Vaquero C. Vaquero Laboratoire d'Immunologie et Oncologie des Maladies Rétrovirales, INSERM U 152, CNRS URA 628, Hôpital Cochin, Paris, France. Search for more papers by this author Author Information F. Paillard1, G. Sterkers1 and C. Vaquero1 1Laboratoire d'Immunologie et Oncologie des Maladies Rétrovirales, INSERM U 152, CNRS URA 628, Hôpital Cochin, Paris, France. The EMBO Journal (1990)9:1867-1872https://doi.org/10.1002/j.1460-2075.1990.tb08312.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We previously showed that the turnover rates of the messengers coding for the T cell receptor (TcR) alpha, beta and gamma, CD4 and CD8 molecules composing the multireceptor complex vary in normal human mature T lymphocytes according to their state of activation. Activation by soluble anti-CD3 which does not induce proliferation, promotes a weak up-modulation of the corresponding five mRNAs. In contrast, activation signals such as anti-CD3 + PMA, which lead to lymphokine mRNA expression and T cell proliferation, promote a decrease of the TcR, CD4 and CD8 mRNA levels within 4 h post-activation, followed by their gradual re-expression. Here we show that the down-modulation of these mRNAs results from early regulation controls at transcriptional and post-transcriptional levels, i.e. through a concomitant inhibition of transcription and destabilization of the mRNA. Moreover, later re-expression of the mRNA results from recovery of transcription and marked increase of the mRNA stability. Finally, down-modulation is specific for TcR, CD4 and CD8 mRNAs, all submitted to similar regulation processes. These results strongly suggest a direct correlation between down-modulation of the multireceptor complex mRNAs, and lymphokine mRNA expression, and cellular proliferation. Previous ArticleNext Article Volume 9Issue 61 June 1990In this issue RelatedDetailsLoading ..." @default.
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• W72800539 title "Transcriptional and post-transcriptional regulation of TcR, CD4 and CD8 gene expression during activation of normal human T lymphocytes." @default.
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