Matches in SemOpenAlex for { <https://semopenalex.org/work/W72812892> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W72812892 endingPage "5" @default.
- W72812892 startingPage "BR91" @default.
- W72812892 abstract "It has been hypothesized that iron is stored in the synovium of patients with rheumatoid arthritis which perpetuates inflamation by aiding the production of oxygen free radicals. Proinflammatory cytokines are produced by macrophages and lymphocytes present within synovium and by mononuclear cells of in synovial fluid from patients with rheumatoid arthritis. There are two known systems for iron uptake. The first involves binding of iron to transferrin and uptake via transferrin receptors. The second involves uptake by low molecular weight organic anions such as ascorbate and citrate (non-transferrin bound uptake).Proinflammatory cytokines (IL-1, IL-6, TNFalpha and interferon gamma) were added to fibroblasts isolated from patients with rheumatoid arthritis and human monocytes in culture and their effect on 59Fe-transferrin and citrate uptake was determined.Proinflammatory cytokines increase transferrin and non-transferrin bound iron uptake into human monocytes and increase transferrin-bound iron uptake by synovial fibroblasts, but have no effect on non-transferrin bound uptake into fibroblasts.Proinflammatory cytokines produced in human rheumatoid arthritis synovium and synovial fluid may contribute to the accumulation of iron that occurs in rheumatoid arthritis synovium which may lead to damage to synovial fibroblasts, macrophages and lymphocytes." @default.
- W72812892 created "2016-06-24" @default.
- W72812892 creator A5018216805 @default.
- W72812892 creator A5082654701 @default.
- W72812892 date "2004-04-01" @default.
- W72812892 modified "2023-09-29" @default.
- W72812892 title "Proinflammatory cytokines increase iron uptake into human monocytes and synovial fibroblasts from patients with rheumatoid arthritis." @default.
- W72812892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15039637" @default.
- W72812892 hasPublicationYear "2004" @default.
- W72812892 type Work @default.
- W72812892 sameAs 72812892 @default.
- W72812892 citedByCount "14" @default.
- W72812892 countsByYear W728128922016 @default.
- W72812892 countsByYear W728128922020 @default.
- W72812892 countsByYear W728128922021 @default.
- W72812892 countsByYear W728128922022 @default.
- W72812892 countsByYear W728128922023 @default.
- W72812892 crossrefType "journal-article" @default.
- W72812892 hasAuthorship W72812892A5018216805 @default.
- W72812892 hasAuthorship W72812892A5082654701 @default.
- W72812892 hasConcept C134018914 @default.
- W72812892 hasConcept C137061746 @default.
- W72812892 hasConcept C142724271 @default.
- W72812892 hasConcept C164027704 @default.
- W72812892 hasConcept C17991360 @default.
- W72812892 hasConcept C185592680 @default.
- W72812892 hasConcept C19702531 @default.
- W72812892 hasConcept C202751555 @default.
- W72812892 hasConcept C203014093 @default.
- W72812892 hasConcept C204787440 @default.
- W72812892 hasConcept C22814914 @default.
- W72812892 hasConcept C2776164576 @default.
- W72812892 hasConcept C2776268809 @default.
- W72812892 hasConcept C2776914184 @default.
- W72812892 hasConcept C2777077863 @default.
- W72812892 hasConcept C2777575956 @default.
- W72812892 hasConcept C2777652487 @default.
- W72812892 hasConcept C2779244956 @default.
- W72812892 hasConcept C2781184567 @default.
- W72812892 hasConcept C32264632 @default.
- W72812892 hasConcept C55493867 @default.
- W72812892 hasConcept C71924100 @default.
- W72812892 hasConceptScore W72812892C134018914 @default.
- W72812892 hasConceptScore W72812892C137061746 @default.
- W72812892 hasConceptScore W72812892C142724271 @default.
- W72812892 hasConceptScore W72812892C164027704 @default.
- W72812892 hasConceptScore W72812892C17991360 @default.
- W72812892 hasConceptScore W72812892C185592680 @default.
- W72812892 hasConceptScore W72812892C19702531 @default.
- W72812892 hasConceptScore W72812892C202751555 @default.
- W72812892 hasConceptScore W72812892C203014093 @default.
- W72812892 hasConceptScore W72812892C204787440 @default.
- W72812892 hasConceptScore W72812892C22814914 @default.
- W72812892 hasConceptScore W72812892C2776164576 @default.
- W72812892 hasConceptScore W72812892C2776268809 @default.
- W72812892 hasConceptScore W72812892C2776914184 @default.
- W72812892 hasConceptScore W72812892C2777077863 @default.
- W72812892 hasConceptScore W72812892C2777575956 @default.
- W72812892 hasConceptScore W72812892C2777652487 @default.
- W72812892 hasConceptScore W72812892C2779244956 @default.
- W72812892 hasConceptScore W72812892C2781184567 @default.
- W72812892 hasConceptScore W72812892C32264632 @default.
- W72812892 hasConceptScore W72812892C55493867 @default.
- W72812892 hasConceptScore W72812892C71924100 @default.
- W72812892 hasIssue "4" @default.
- W72812892 hasLocation W728128921 @default.
- W72812892 hasOpenAccess W72812892 @default.
- W72812892 hasPrimaryLocation W728128921 @default.
- W72812892 hasRelatedWork W2074342345 @default.
- W72812892 hasRelatedWork W2101840353 @default.
- W72812892 hasRelatedWork W2104743752 @default.
- W72812892 hasRelatedWork W2134616784 @default.
- W72812892 hasRelatedWork W2155173950 @default.
- W72812892 hasRelatedWork W2403342154 @default.
- W72812892 hasRelatedWork W2414565446 @default.
- W72812892 hasRelatedWork W2530809683 @default.
- W72812892 hasRelatedWork W2989683811 @default.
- W72812892 hasRelatedWork W72812892 @default.
- W72812892 hasVolume "10" @default.
- W72812892 isParatext "false" @default.
- W72812892 isRetracted "false" @default.
- W72812892 magId "72812892" @default.
- W72812892 workType "article" @default.