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- W72837440 abstract "Serum soluble transferrin receptor (sTfR) is elevated during increased cellular iron demands and erythropoiesis. It is recommended as a sensitive and accurate measure of iron deficiency in populations. The lack of assay standardization and of representative data on the distribution of sTfR in at-risk populations limits its use. Using data from NHANES 2003–2008, we examined the distribution of sTfR and developed assay-specific cutoff values for defining elevated sTfR in two US populations groups: children 1–5 y (n=2042) and non-pregnant women 12–49 y (n=5656). On average, children had higher geometric mean sTfR concentrations (4.20 mg/L; CI: 4.15–4.26) than non-pregnant women (3.42 mg/L; CI: 3.37–3.48) (p<0.001). Among children, those aged 1–2 y (compared to those aged 3–5 y), boys (compared to girls), and non-Hispanic black [NHB] children (compared to non-Hispanic white [NHW] and Mexican-American [MA] children) had higher sTfR concentrations. Among non-pregnant women, adolescents (12–19 y) had higher sTfR concentrations than adults aged 20–34 y but not compared to adults aged 35–49 y; NHB women (compared to NHW and MA women) and multiparous women (compared to nulliparous women) had higher sTfR concentrations. The derived cutoff values (95th percentile in a defined healthy reference population) for elevated sTfR in the US were 5.74 mg/L for children 1–5 y and 4.94 mg/L for non-pregnant women 12–49 y." @default.
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- W72837440 date "2012-04-01" @default.
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- W72837440 title "Serum soluble transferrin receptor concentrations in US preschool children and non‐pregnant women of childbearing age from the National Health and Nutrition Examination Survey 2003–2008" @default.
- W72837440 doi "https://doi.org/10.1096/fasebj.26.1_supplement.641.1" @default.
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