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- W72839608 endingPage "170" @default.
- W72839608 startingPage "149" @default.
- W72839608 abstract "The regulation of sleep, body temperature, and metabolism is intertwined on functional, structural, and behavioral levels. The hypothalamus emerges as a key brain region that coordinates these functions by integrating central and peripheral signals. Increasing evidence suggests that products of the preproghrelin gene provide important contribution to this integrative function. In this review, we present evidence from human and animal studies supporting the role of ghrelin in the regulation of (1) sleep–wake activity, (2) circadian rhythms, and (3) metabolism and body temperature. Central ghrelinergic mechanisms—as part of the hypothalamic ghrelin–orexin–neuropeptide Y circuit—play a role in promoting wakefulness and feeding. Ghrelin modulates the activity of the suprachiasmatic nucleus but it is not a crucial component of or a key input signal to the food-entrainable oscillator. Products of the preproghrelin gene, particularly obestatin, are involved in maintaining normal body temperature and metabolism under conditions when increased metabolic heat production is required. Our understanding of the physiological role of the preproghrelin gene products expanded remarkably in the last decade, yet, full comprehension of their role in the regulation of vigilance, circadian clocks, and body temperature remains incomplete." @default.
- W72839608 created "2016-06-24" @default.
- W72839608 creator A5012696927 @default.
- W72839608 creator A5078438058 @default.
- W72839608 date "2012-01-01" @default.
- W72839608 modified "2023-09-25" @default.
- W72839608 title "Ghrelin Regulation of Sleep, Circadian Clock, and Body Temperature" @default.
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