FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W72869980> ?p ?o ?g. }

• W72869980 endingPage "2483" @default.
• W72869980 startingPage "2474" @default.
• W72869980 abstract "This study sought to investigate the evolving pattern over time of on-clopidogrel platelet reactivity (PR) and its relationship with genotype and clinical outcomes after percutaneous coronary intervention. Whether on-clopidogrel PR and role of genotype differ over time is unknown. On-clopidogrel PR before percutaneous coronary intervention, and 1 and 6 months thereafter via VerifyNow P2Y12 (Accumetrics Inc., San Diego, California), CYP2C19*2, *17, CYP3A5*3, and ABCB1 polymorphisms were evaluated in 300 patients. Death, stroke, myocardial infarction, and bleedings were assessed up to 1 year. On-clopidogrel PR varied significantly over time, being higher at baseline than at 1 and 6 months after. From baseline to 1 month, 83 of 300 patients varied their response status. This was mainly due to baseline poor responders becoming full responders (75 of 83). Genotype justifies roughly 18% of this trend. CYP2C19*2 and *17 influence on PR was consistent over time, whereas that of ABCB1 appeared of greater impact at baseline. On-clopidogrel PR at 1 month independently best predicts ischemic and bleeding events. We found a therapeutic window (86 to 238 P2Y12 reactivity units) with a lower incidence of both ischemic and bleeding complications. A risk score was created by combining genotype (ABCB1 and CYP2C19*2), baseline PR, and creatinine clearance to predict 1-month poor responsiveness and 1-year poor prognosis. In patients at steady state for clopidogrel undergoing percutaneous coronary intervention, PR decreases from baseline to 1 month. Genotype influences ≈18% of this trend. On-clopidogrel PR at 1 month is the strongest predictor of adverse outcomes, and this can be predicted by combining genotype to baseline phenotype and clinical variables." @default.
• W72869980 created "2016-06-24" @default.
• W72869980 creator A5002162807 @default.
• W72869980 creator A5032028897 @default.
• W72869980 creator A5032916778 @default.
• W72869980 creator A5056907878 @default.
• W72869980 creator A5057403590 @default.
• W72869980 creator A5061105232 @default.
• W72869980 creator A5062655570 @default.
• W72869980 creator A5064174878 @default.
• W72869980 creator A5075033637 @default.
• W72869980 creator A5085509005 @default.
• W72869980 date "2011-06-01" @default.
• W72869980 modified "2023-10-18" @default.
• W72869980 title "Prospective Evaluation of On-Clopidogrel Platelet Reactivity Over Time in Patients Treated With Percutaneous Coronary Intervention" @default.
• W72869980 cites W1974655135 @default.
• W72869980 cites W1985520875 @default.
• W72869980 cites W200979310 @default.
• W72869980 cites W2017294431 @default.
• W72869980 cites W2026222911 @default.
• W72869980 cites W2076517423 @default.
• W72869980 cites W2099022345 @default.
• W72869980 cites W2105523329 @default.
• W72869980 cites W2113513640 @default.
• W72869980 cites W2141883929 @default.
• W72869980 cites W2154940301 @default.
• W72869980 cites W2159858918 @default.
• W72869980 cites W2162756930 @default.
• W72869980 cites W2164386459 @default.
• W72869980 cites W2165620610 @default.
• W72869980 cites W33605581 @default.
• W72869980 cites W67811773 @default.
• W72869980 cites W81845835 @default.
• W72869980 cites W9177793 @default.
• W72869980 doi "https://doi.org/10.1016/j.jacc.2010.12.047" @default.
• W72869980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21679849" @default.
• W72869980 hasPublicationYear "2011" @default.
• W72869980 type Work @default.
• W72869980 sameAs 72869980 @default.
• W72869980 citedByCount "311" @default.
• W72869980 countsByYear W728699802012 @default.
• W72869980 countsByYear W728699802013 @default.
• W72869980 countsByYear W728699802014 @default.
• W72869980 countsByYear W728699802015 @default.
• W72869980 countsByYear W728699802016 @default.
• W72869980 countsByYear W728699802017 @default.
• W72869980 countsByYear W728699802018 @default.
• W72869980 countsByYear W728699802019 @default.
• W72869980 countsByYear W728699802020 @default.
• W72869980 countsByYear W728699802021 @default.
• W72869980 countsByYear W728699802022 @default.
• W72869980 countsByYear W728699802023 @default.
• W72869980 crossrefType "journal-article" @default.
• W72869980 hasAuthorship W72869980A5002162807 @default.
• W72869980 hasAuthorship W72869980A5032028897 @default.
• W72869980 hasAuthorship W72869980A5032916778 @default.
• W72869980 hasAuthorship W72869980A5056907878 @default.
• W72869980 hasAuthorship W72869980A5057403590 @default.
• W72869980 hasAuthorship W72869980A5061105232 @default.
• W72869980 hasAuthorship W72869980A5062655570 @default.
• W72869980 hasAuthorship W72869980A5064174878 @default.
• W72869980 hasAuthorship W72869980A5075033637 @default.
• W72869980 hasAuthorship W72869980A5085509005 @default.
• W72869980 hasBestOaLocation W728699801 @default.
• W72869980 hasConcept C126322002 @default.
• W72869980 hasConcept C140840227 @default.
• W72869980 hasConcept C164705383 @default.
• W72869980 hasConcept C2777849778 @default.
• W72869980 hasConcept C2778905298 @default.
• W72869980 hasConcept C2780400711 @default.
• W72869980 hasConcept C35294091 @default.
• W72869980 hasConcept C49059817 @default.
• W72869980 hasConcept C500558357 @default.
• W72869980 hasConcept C526171541 @default.
• W72869980 hasConcept C62231903 @default.
• W72869980 hasConcept C71924100 @default.
• W72869980 hasConceptScore W72869980C126322002 @default.
• W72869980 hasConceptScore W72869980C140840227 @default.
• W72869980 hasConceptScore W72869980C164705383 @default.
• W72869980 hasConceptScore W72869980C2777849778 @default.
• W72869980 hasConceptScore W72869980C2778905298 @default.
• W72869980 hasConceptScore W72869980C2780400711 @default.
• W72869980 hasConceptScore W72869980C35294091 @default.
• W72869980 hasConceptScore W72869980C49059817 @default.
• W72869980 hasConceptScore W72869980C500558357 @default.
• W72869980 hasConceptScore W72869980C526171541 @default.
• W72869980 hasConceptScore W72869980C62231903 @default.
• W72869980 hasConceptScore W72869980C71924100 @default.
• W72869980 hasIssue "25" @default.
• W72869980 hasLocation W728699801 @default.
• W72869980 hasLocation W728699802 @default.
• W72869980 hasOpenAccess W72869980 @default.
• W72869980 hasPrimaryLocation W728699801 @default.
• W72869980 hasRelatedWork W175512219 @default.
• W72869980 hasRelatedWork W1949370008 @default.
• W72869980 hasRelatedWork W1982744000 @default.
• W72869980 hasRelatedWork W2007353900 @default.
• W72869980 hasRelatedWork W2017953431 @default.

• next