Matches in SemOpenAlex for { <https://semopenalex.org/work/W72876089> ?p ?o ?g. }
- W72876089 abstract "Nowadays a wide variety of vaccines exist to prevent diseases. However, the correlates of protection in immunisation are an unresolved issue. This hinders the development of new vaccines and improvement of current vaccines. To measure the efficacy of newly developed vaccines, several methods can be used, such as determining the antibody titer, measure the CTL activity and determine the cytokine production. However, all of these methods have their limitations. The antibody titer does not correlate to the efficacy of the vaccine. Moreover, titers can be measured in various ways, making them incomparable. Also, only the humoral response is measured. This makes it limited to asses the complete protection. To indicating the strength of the cellular response, CTL activity can be determined. This is however, an inconvenient method to use and contradicting results were found in human studies when correlating it to the efficacy of vaccines. The role of cytokines during an immune response is still not clear and therefore would not be a good parameter to determine the efficacy. Another aspect with regard to immunisation, are the influence of factors such as age, route of delivery and lifestyle. There exact influence, however, needs to be determined yet. Therefore, more research is necessary to determine the specificity of parameters and the affecting factors. Identifying the optimal correlates of protection per vaccine is recommended. This would be easier if the different methods were optimised and standardised. Using several methods will extract the mechanism behind immunisation, making it easier to develop new vaccines." @default.
- W72876089 created "2016-06-24" @default.
- W72876089 creator A5062587471 @default.
- W72876089 date "2009-03-02" @default.
- W72876089 modified "2023-09-27" @default.
- W72876089 title "Search for correlates of protection" @default.
- W72876089 cites W1513438656 @default.
- W72876089 cites W1523000780 @default.
- W72876089 cites W1538764015 @default.
- W72876089 cites W1543325210 @default.
- W72876089 cites W1554176415 @default.
- W72876089 cites W1559556959 @default.
- W72876089 cites W1903636206 @default.
- W72876089 cites W1964004218 @default.
- W72876089 cites W1964350435 @default.
- W72876089 cites W1967945305 @default.
- W72876089 cites W1969372348 @default.
- W72876089 cites W1969977433 @default.
- W72876089 cites W1975618743 @default.
- W72876089 cites W1975628385 @default.
- W72876089 cites W1976000655 @default.
- W72876089 cites W1980474846 @default.
- W72876089 cites W1981282559 @default.
- W72876089 cites W1981811803 @default.
- W72876089 cites W1983737583 @default.
- W72876089 cites W1986332290 @default.
- W72876089 cites W1987016144 @default.
- W72876089 cites W1989069932 @default.
- W72876089 cites W1991253838 @default.
- W72876089 cites W1991507966 @default.
- W72876089 cites W1991522582 @default.
- W72876089 cites W1993066166 @default.
- W72876089 cites W1994496101 @default.
- W72876089 cites W1995609742 @default.
- W72876089 cites W1995881036 @default.
- W72876089 cites W1996728964 @default.
- W72876089 cites W1999546448 @default.
- W72876089 cites W2003343560 @default.
- W72876089 cites W2004545272 @default.
- W72876089 cites W2005284010 @default.
- W72876089 cites W2006486304 @default.
- W72876089 cites W2009960465 @default.
- W72876089 cites W2018625467 @default.
- W72876089 cites W2019878496 @default.
- W72876089 cites W2025466710 @default.
- W72876089 cites W2025481087 @default.
- W72876089 cites W2027741520 @default.
- W72876089 cites W2029212574 @default.
- W72876089 cites W2029601739 @default.
- W72876089 cites W2033173747 @default.
- W72876089 cites W2040752322 @default.
- W72876089 cites W2041854753 @default.
- W72876089 cites W2047477823 @default.
- W72876089 cites W2048242438 @default.
- W72876089 cites W2056969658 @default.
- W72876089 cites W2063937263 @default.
- W72876089 cites W2067018191 @default.
- W72876089 cites W2081651556 @default.
- W72876089 cites W2085962294 @default.
- W72876089 cites W2095557519 @default.
- W72876089 cites W2097010288 @default.
- W72876089 cites W2098832466 @default.
- W72876089 cites W2100722902 @default.
- W72876089 cites W2105054884 @default.
- W72876089 cites W2106444512 @default.
- W72876089 cites W2106859466 @default.
- W72876089 cites W2110266051 @default.
- W72876089 cites W2110745776 @default.
- W72876089 cites W2111134819 @default.
- W72876089 cites W2112333290 @default.
- W72876089 cites W2123179119 @default.
- W72876089 cites W2128666074 @default.
- W72876089 cites W2146456832 @default.
- W72876089 cites W2155047639 @default.
- W72876089 cites W2158244716 @default.
- W72876089 cites W2159984475 @default.
- W72876089 cites W2169940372 @default.
- W72876089 cites W2170456252 @default.
- W72876089 cites W2200403145 @default.
- W72876089 cites W2264518461 @default.
- W72876089 cites W2411673182 @default.
- W72876089 hasPublicationYear "2009" @default.
- W72876089 type Work @default.
- W72876089 sameAs 72876089 @default.
- W72876089 citedByCount "0" @default.
- W72876089 crossrefType "dissertation" @default.
- W72876089 hasAuthorship W72876089A5062587471 @default.
- W72876089 hasConcept C112930515 @default.
- W72876089 hasConcept C147969180 @default.
- W72876089 hasConcept C159654299 @default.
- W72876089 hasConcept C167672396 @default.
- W72876089 hasConcept C203014093 @default.
- W72876089 hasConcept C22889606 @default.
- W72876089 hasConcept C2780441014 @default.
- W72876089 hasConcept C32611913 @default.
- W72876089 hasConcept C71924100 @default.
- W72876089 hasConcept C8891405 @default.
- W72876089 hasConceptScore W72876089C112930515 @default.
- W72876089 hasConceptScore W72876089C147969180 @default.
- W72876089 hasConceptScore W72876089C159654299 @default.