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- W73088879 abstract "16133 Background: Strontium-89 (Sr-89) is a radionuclide particle that precipitates in bone, and has a role in the control of pain in prostate cancer patients. Several studies reported on additional beneficial effects in combination with chemotherapy. There is little information regarding the combined treatment of Sr-89 and Gemcitabine in prostate cancer. The aim of our study was to evaluate the efficacy of Sr-89 given in combination with Gemcitabine in patients with hormonal-resistant prostate cancer with painful bony metastases. Methods: All patients with hormonal-resistant prostate cancer were eligible to this study.Gemcitabine was given at a loading dose of 1000 mg/m2 on day 1, and 100 (dose level 1) or 200 (dose level 2) mg/m2 on day 29 and once weekly for 7 weeks. A single dose of strontium-89 (4mCi) was administered on Day 8. Results: 9 patients were registered. 5 patients were treated at Dose Level 1, without dose-limiting toxicity. Pain relief was achieved in 60% (3/5). Decrease of PSA >50% was observed in 40% (2/5). 4 patients were treated at Dose Level 2. Pain relief was achieved in 75% (3/4). Decrease of PSA >50% was observed in 25% (1/4). Side effects were drug eruption in one patient and non specific chest pain. Conclusions: The combination of Sr-89 and Gemcitabine was relatively well tolerated at the doses of 4 mCi and 100 or 200 mg/m2 respectively and was associated with pain relief and a decrease of PSA. Further studies investigating this regimen are warranted. No significant financial relationships to disclose." @default.
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- W73088879 date "2008-05-20" @default.
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- W73088879 title "Strontium-89 combined with gemcitabine in hormonal-resistant prostate cancer: Results of a phase I-II study" @default.
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- W73088879 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.16133" @default.
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