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- W7313267 abstract "Fertility in men with congenital adrenal hyperplasia due to 21-hydroxylase deficiency can be impaired. Testicular adrenal rest tumors are the most frequent cause of impaired fertility. Their location adjacent to the testicular mediastinum, and their steroid-producing properties, may interfere with spermatogenesis and Leydig cell function. It is sometimes accompanied by hypergonadotropic hypogonadism. Hypogonadotropic hypogonadotropism is a second major cause of impaired fertility, resulting from suppression of the hypothalamic–pituitary–gonadal axis by adrenal androgen excess. Other testicular abnormalities and psychological factors, such as poor adherence, compliance, and transition problems, may also contribute to impaired fertility. Treatment consists of intensification of glucocorticoid treatment and assisted reproduction techniques. Genetic testing of the asymptomatic female partner is recommended for couples planning to have children." @default.
- W7313267 created "2016-06-24" @default.
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- W7313267 date "2004-01-01" @default.
- W7313267 modified "2023-09-26" @default.
- W7313267 title "Hypogonadism in Males With Congenital Adrenal Hyperplasia" @default.
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- W7313267 doi "https://doi.org/10.1007/978-1-59259-727-7_7" @default.
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