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- W73142112 abstract "ASCORBIC ACID IS KNOWN TO BE AN IMPORTANT CONSTITUTENT OF AQUTEOUS HUMNIOR in diurnal mammals including humans.1-14 WVhat is known about ocular ascorbic acid has been derived largely froim one of two assay techniques. In one assay, the samnple is titrated with an oxidizer in the presence of a redox indicator such as dichloroindophenol.15 In the other assay, the ascorbate is separated by chromatography and detected by its absorbance of light at 240 nN1.6 Both techniques share the same disadvantagethe eye must be punctured to obtain a sample. This necessity limits the kinds of studies which can be done. Repeated studies in a single eye or longitudinal studies in humans are not feasible. The abundance of ascorbate in aqueous humor of some species led us to speculate that one might exploit some physical or chemical property of this weak reducing agent in order to measure it. One of us (Penniston) suggested that we test the feasibility of carrying out Raman spectroscopy in the living eye. We explored the possibility of amplifying the Raman peak of ascorbate by employing a carefully tuned pair of dye lasers, coherent anti-Stokes Raman spectroscopy (CARS)'8 and stimulated Raman spectroscopy (SRS). 19 However, preliminary calculations made it seem unlikely that any Raman technique could be safely adapted to the living eye. Attention was directed to the possibility of finding a fluorescent redox probe. We sought a compound which would undergo a spectral shift by chemical or physical interaction with ascorbate. Penniston reasoned that the fluorescent oxidizing agent resazurin, which can be reduced to an*From the Nlao Clinic and NMavo Fotindation, Rochester. NMinnesota." @default.
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- W73142112 date "1986-01-01" @default.
- W73142112 modified "2023-09-27" @default.
- W73142112 title "Ascorbic acid in the anterior chamber: can it be measured noninvasively?" @default.
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