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• W73147299 abstract "A Drosophila sejtkozvetitette immunvalaszanak szabalyozasat vizsgaltuk valamint molekularis immunologiai es genetikai ismeretek elsajatitasat es projekt epiteset tettuk lehetőve a tudomany irant erdeklődő diakok es kutatok szamara.Adult Drosophila versejtjeire, makrofagokra es a lamellocitakra jellemző markereket azonositottunk.Az L5 antigen a lamellocitak differencialodasanak a szuppresszora.A P1 antigenről (Nimrod) megallapitottuk, hogy reszt vesz a fagocitozisban.A P1 molekula jellegzetes motivumot hordoz (Nim-repeat),mely egy szupercsaladot hataroz meg:tagjai a kodolo gen kozvetlen kornyezeteben helyezkednek el. Javaslatot tettunk a Nim repeat kialakulasanak a modelljere,leirtuk a Nimrod szuprcsalad lehetseges evoluciojat.A verkepzest es a versejtek funkcioit szabalyozo geneket es molekulakat azonositottunk.Egy epigenetikus regulatorrol megallapitottuk,hogy a versejtek osztodasat,egy mestergenről pedig,hogy a lamellocitak differencialodasat szabalyozza.RNSi mutansgyűjtemenyben a szesszilis szovet kialakulasaban resztvevő gentermeket azonositottunk.Megallapitottuk, hogy a lamellocitak a szesszilis szovetből szarmaznak,effektorsejtekke tortenő differencialodasuk lepesei immunologiai markerekkel nyomonkovethetők.Eddig nem ismert sejteket talaltunk Drosophila fajokban es a jellemzesukre alkalmas immunologiai markereket azonositottunk.Az altalunk felismert markereket a Drosophila versejt-differencialodasat es funkcioit vizsgalo laboratoriumokban rutinszerűen hasznaljak. | We studied the regulation cellular immunity of Drosophila and developed a training-unit based on the research and teaching experience of our multidisciplinary team, with a broad interest in molecular immunology. Results: We identified markers for embryonic macrophages, lamellocytes and blood cells of the adult fly. We described the L5 antigen as a suppressor of lamellocyte development. We defined P1 antigen (Nimrod) as a phagocytosis receptor with a structurally and phylogenetically conserved characteristic unit, the Nim repeat. The repeat defines a superfamily with members located in the close proximity of the p1 gene. We suggested a model for the origin of the Nim repeat, and described the possible evolution of the superfamily. We defined an epigenetic regulator of blood cell differentiation and a master gene regulating the development of lamellocytes. We defined the sessile hematopoietic tissue as the source of lamellocytee precursors. We characterized sequential events in lamellocyte development from sessile stem cells to mature lamellocytes by sequential expression of lamellocyte antigens. We found so far undefined cell types in Drosophila species and developed immunological markers for them. The hemocyte markers defined in our laboratory are used worldwide routinely in studies of blood cell development and function in Drosophila." @default.
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• W73147299 date "2009-01-01" @default.
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• W73147299 title "A Drosophila melanogaster sejtes immunitása = The cellular immunity of Drosophila melanogaster" @default.
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