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- W73160596 abstract "The in vivo effect of several prostaglandin inhibitory drugs on the hemopoietic stem cell was studied in SJL/J mice. Repeated intramuscular administration of Indomethacin increased the total number of bone marrow (BM) and spleen pluripotent hemopoietic stem cells (CFUS). The number of spleen colonies in lethally-irradiated normal BM recipients, which had been treated with Indomethacin, Aspirin or Flufenamic acid (all prostaglandin inhibitory drugs), was significantly greater than controls' spleen colonies. After exposure of SJL/J mice to different amounts of irradiation, more endogenous spleen colonies and a greater splenic weight were found among mice which had been treated with Indomethacin in comparison to PBS-treated mice. According to our results, treatment with prostaglandin inhibitory drugs stimulates murine hemopoietic stem cell proliferation and enhances stem cell recovery following irradiation." @default.
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- W73160596 date "1983-10-01" @default.
- W73160596 modified "2023-10-12" @default.
- W73160596 title "Enhancement of hemopoietic stem cell proliferation by prostaglandin inhibitory drugs." @default.
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