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- W732740 endingPage "90" @default.
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- W732740 abstract "Over the past decade it has become known that phospholipids, present in the plasma membrane, play an essential part in receptor signal transduction. Firstly, changes in plasma membrane phospholipid composition alter the physicochemical properties of the lipid bilayer and the lipid domains of membrane proteins (receptors, ion channels, enzymes etc.), thereby influencing cell function [1]. Secondly, phospholipids originate several intracellular messenger molecules [2–5]. These phospholipid metabolites may stem from the headgroup, such as inositol 1,4,5-trisphosphate (Ins(l,4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (Ins(l,3,4,5)P4), or they may be of a lipid nature, such as certain non-esterified fatty acids (NEFAs), lysophospholipids (lysoPLs), sn-l,2-diacylglycerol (DAG), phosphatidic acid (PtdOH) and eicosanoids. The presence of the enzymes responsible for the formation of above mentioned metabolites in myocardial cells has in most cases been confirmed only recently [6–9]. Moreover, with regard to the knowledge on the mechanisms of stimulus-response coupling through phospholipid pathways, only a corner of the veil has been lifted." @default.
- W732740 created "2016-06-24" @default.
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- W732740 date "1993-01-01" @default.
- W732740 modified "2023-09-27" @default.
- W732740 title "Phospholipase D: A New Avenue to the Phospholipid Signalling Pathways in the Myocardium" @default.
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- W732740 doi "https://doi.org/10.1007/978-1-4615-3090-9_7" @default.
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