Matches in SemOpenAlex for { <https://semopenalex.org/work/W73320011> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W73320011 abstract "The observation that mitochondrial oxidative phosphorylation in vivo is dependent on oxygen tension throughout the physiological range (Wilson et al., 1979a , 1979b ) has made this metabolic pathway the most probable candidate for the tissue oxygen sensor in the regulation of local blood flow. We have utilized the oxygen dependent regulatory system for coronary blood flow to examine this possibility. Alterations in coronary flow were induced by: 1. Varied work load; 2. Infusion of Amytal (an inhibitor of mitochondrial respiration); 3. Infusion of DNP; 4. Hypoxia. Increased work load caused increased coronary flow with no decrease in effluent oxygen tension while Amytal infusion and hypoxia caused vasodilation with increased and decreased O2 tension respectively. This indicates that oxygen tension per se cannot be responsible for the observed vasodilation. Tissue energy metabolism was evaluated by measuring metabolite levels in hearts which were freeze-clamped in each state of perfusion. In all four methods of vasodilation, a decrease in cellular energy state ratio ([ATP]f/[ADP]f[Pi]) expressed as the calculated ratio of free adenine nucleotides, was observed for conditions which increased flow. Systematic variation of work load, Amytal or DNP concentration resulted in quantitatively the same correlation between tissue [ATP]f/[ADP]f[Pi] and coronary flow. It is concluded that mitochondrial oxidative phosphorylation is the oxygen sensor for the regulation of coronary blood flow by tissue oxygen tension. Infusion of adenosine, a known coronary vasodilator, induced vasodilation which was completely blocked by theophylline.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W73320011 created "2016-06-24" @default.
- W73320011 creator A5039737565 @default.
- W73320011 creator A5079229712 @default.
- W73320011 creator A5091130384 @default.
- W73320011 date "1984-01-01" @default.
- W73320011 modified "2023-10-16" @default.
- W73320011 title "Mitochondrial Oxidative Phosphorylation: Tissue Oxygen Sensor for Regulation of Coronary Flow" @default.
- W73320011 cites W126925266 @default.
- W73320011 cites W1517594284 @default.
- W73320011 cites W1995272538 @default.
- W73320011 cites W1995640820 @default.
- W73320011 cites W2019252461 @default.
- W73320011 cites W2068182585 @default.
- W73320011 cites W2149274776 @default.
- W73320011 cites W2335088247 @default.
- W73320011 cites W2416951256 @default.
- W73320011 cites W2419252757 @default.
- W73320011 cites W2432195370 @default.
- W73320011 doi "https://doi.org/10.1007/978-1-4684-1188-1_30" @default.
- W73320011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6731096" @default.
- W73320011 hasPublicationYear "1984" @default.
- W73320011 type Work @default.
- W73320011 sameAs 73320011 @default.
- W73320011 citedByCount "8" @default.
- W73320011 countsByYear W733200112013 @default.
- W73320011 crossrefType "book-chapter" @default.
- W73320011 hasAuthorship W73320011A5039737565 @default.
- W73320011 hasAuthorship W73320011A5079229712 @default.
- W73320011 hasAuthorship W73320011A5091130384 @default.
- W73320011 hasConcept C120770815 @default.
- W73320011 hasConcept C126322002 @default.
- W73320011 hasConcept C146957229 @default.
- W73320011 hasConcept C178790620 @default.
- W73320011 hasConcept C185592680 @default.
- W73320011 hasConcept C2776151105 @default.
- W73320011 hasConcept C28859421 @default.
- W73320011 hasConcept C2909076160 @default.
- W73320011 hasConcept C2993207723 @default.
- W73320011 hasConcept C540031477 @default.
- W73320011 hasConcept C55493867 @default.
- W73320011 hasConcept C57600042 @default.
- W73320011 hasConcept C71924100 @default.
- W73320011 hasConcept C7836513 @default.
- W73320011 hasConceptScore W73320011C120770815 @default.
- W73320011 hasConceptScore W73320011C126322002 @default.
- W73320011 hasConceptScore W73320011C146957229 @default.
- W73320011 hasConceptScore W73320011C178790620 @default.
- W73320011 hasConceptScore W73320011C185592680 @default.
- W73320011 hasConceptScore W73320011C2776151105 @default.
- W73320011 hasConceptScore W73320011C28859421 @default.
- W73320011 hasConceptScore W73320011C2909076160 @default.
- W73320011 hasConceptScore W73320011C2993207723 @default.
- W73320011 hasConceptScore W73320011C540031477 @default.
- W73320011 hasConceptScore W73320011C55493867 @default.
- W73320011 hasConceptScore W73320011C57600042 @default.
- W73320011 hasConceptScore W73320011C71924100 @default.
- W73320011 hasConceptScore W73320011C7836513 @default.
- W73320011 hasLocation W733200111 @default.
- W73320011 hasLocation W733200112 @default.
- W73320011 hasOpenAccess W73320011 @default.
- W73320011 hasPrimaryLocation W733200111 @default.
- W73320011 hasRelatedWork W130182483 @default.
- W73320011 hasRelatedWork W2001913780 @default.
- W73320011 hasRelatedWork W2019252461 @default.
- W73320011 hasRelatedWork W2024308913 @default.
- W73320011 hasRelatedWork W2078310082 @default.
- W73320011 hasRelatedWork W2412786613 @default.
- W73320011 hasRelatedWork W2414295860 @default.
- W73320011 hasRelatedWork W4200354416 @default.
- W73320011 hasRelatedWork W560139501 @default.
- W73320011 hasRelatedWork W73320011 @default.
- W73320011 isParatext "false" @default.
- W73320011 isRetracted "false" @default.
- W73320011 magId "73320011" @default.
- W73320011 workType "book-chapter" @default.